Reactome | Polyglycyl-TUBB6 [cytosol]

Polyglycyl-TUBB6 [cytosol]

Stable Identifier

R-HSA-8867396

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBB6, beta tubulin 6

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Homo sapiens)
      - Polyglycylated microtubule [cytosol] (Homo sapiens)
        
        Polyglycylated microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglycyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglycyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglycyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglycyl-TUBB6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BUF5 TUBB6

Gene Names

TUBB6

Chain

chain:1-446

Reference Genes

BioGPS Gene:84617 TUBB6

COSMIC (genes):TUBB6 TUBB6

CTD Gene:84617 TUBB6

dbSNP Gene:84617 TUBB6

ENSEMBL:ENSG00000176014 TUBB6

HGNC:20776 TUBB6

KEGG Gene (Homo sapiens):84617 TUBB6

Monarch:84617 TUBB6

NCBI Gene:84617 TUBB6

OMIM:615103 TUBB6

UCSC:Q9BUF5 TUBB6

Reference Transcript

Other Identifiers

0006620039

11715932_s_at

11747072_s_at

16851081

209191_at

2916784

33678_i_at

3779580

3779581

3779583

3779584

3779591

3779592

3779593

43355_s_at

8020220

84617

A_23_P254271

A_24_P313756

GE61273

GO:0000166

GO:0000226

GO:0000278

GO:0003674

GO:0003924

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0007049

GO:0008150

GO:0043167

GO:0043226

GO:0070062

ILMN_1697132

ILMN_1699489

ILMN_1702636

PH_hs_0014153

g12803638_3p_at

Participant Of

hasCandidate

Polyglycyl beta tubulin [cytosol]

Other forms of this molecule

TUBB6 folding intermediate [cytosol]

TUBB6 unfolded [cytosol]

TUBB6 [cytosol]

TUBB6 [axonemal microtubule]

Polyglutamyl-TUBB6 [cytosol]

Inferred To

Polyglycyl-TUBB6 [cytosol] (Plasmodium falciparum)

TUB2 [cytosol] (Saccharomyces cerevisiae)

Tubb6 [cytosol] (Mus musculus)

Tubb6 [cytosol] (Rattus norvegicus)

nda3 [cytosol] (Schizosaccharomyces pombe)

Homologues of Polyglycyl-TUBB6 [cytosol] (Plasmodium falciparum)

TUBB6 [cytosol] (Canis familiaris)

TUBB6 [cytosol] (Sus scrofa)

Modified Residues

Name

L-isoglutamyl-polyglycine at unknown position

PsiMod Name

L-isoglutamyl-polyglycine

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-isoglutamyl-polyglycine.

Cross References

RefSeq

NP_001290455.1, NP_001290459.1, NP_001290458.1, NP_001290454.1, NP_001290457.1, NP_001290453.1, NP_115914.1, NP_001290456.1

Target Pathogen

57c0987cbe737e1cc0a98056, 57c0ab8fbe737e1cc0a9d73e, 57c0a8f7be737e1cc0a9ad2c, 5b2801b2be737e35a6de77f1, 57c0a8f7be737e1cc0a9ad2d, 5b354852be737e166372e78e, 5b354852be737e166372e74d

OpenTargets

ENSG00000176014

HPA

ENSG00000176014-TUBB6

GeneCards

Q9BUF5

Ensembl

ENSP00000318697, ENSG00000176014, ENST00000317702

PRO

Q9BUF5

HMDB Protein

HMDBP08049

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P04792 HSPB1	3	p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.547	3
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3

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