Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Polyglutamyl-TUBB2B [cytosol]
Stable Identifier
R-HSA-8867426
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TUBB2B, beta tubulin 2B
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
CCPs deglutamylate tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBB2B [cytosol] (Homo sapiens)
Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBB2B [cytosol] (Homo sapiens)
TTLLs polyglutamylate tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBB2B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BVA1 TUBB2B
Gene Names
TUBB2B
Chain
chain:1-445
Reference Genes
BioGPS Gene:347733 TUBB2B
COSMIC (genes):TUBB2B TUBB2B
CTD Gene:347733 TUBB2B
dbSNP Gene:347733 TUBB2B
ENSEMBL:ENSG00000137285 TUBB2B
ENSEMBL_homo_sapiens_GENE:ENSG00000137285.11 TUBB2B
HGNC:30829 TUBB2B
KEGG Gene (Homo sapiens):347733 TUBB2B
Monarch:347733 TUBB2B
NCBI Gene:347733 TUBB2B
OMIM:612850 TUBB2B
UCSC:Q9BVA1 TUBB2B
Reference Transcript
RefSeq:NM_178012.4 TUBB2B
Other Identifiers
11725298_x_at
17015158
202154_PM_x_at
202154_x_at
209372_PM_x_at
209372_x_at
213476_3p_x_at
213476_PM_x_at
213476_x_at
214023_PM_x_at
214023_x_at
2939216
2939217
2939224
2939234
2939235
2939236
2939245
2939246
2939248
2939250
2939256
2939257
33678_i_at
347733
39332_at
4050505
429_f_at
471_f_at
8123651
A_23_P501276
A_24_P314477
GE60053
GO:0000166
GO:0000226
GO:0000278
GO:0001764
GO:0003824
GO:0003924
GO:0005198
GO:0005200
GO:0005515
GO:0005525
GO:0005634
GO:0005737
GO:0005856
GO:0005874
GO:0007010
GO:0007017
GO:0007399
GO:0015630
GO:0016787
GO:0021987
GO:0023052
GO:0030154
GO:0043226
GO:0045171
GO:0046872
GO:0046982
GO:0048856
GO:0048870
GO:0050804
GO:0072686
GO:0098685
GO:1902669
GO:1990403
HMNXSV003055194
Hs.179661.3.S1_3p_x_at
Hs.179661.4.S1_3p_a_at
Hs.179661.4.S1_3p_x_at
ILMN_1680874
PH_hs_0023602
TC06001228.hg
TC06003365.hg
TC06003368.hg
TC06003369.hg
Participates
as a candidate of
Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
Other forms of this molecule
TUBB2B folding intermediate [cytosol]
TUBB2B unfolded [cytosol]
Polyglycyl-TUBB2B [cytosol]
TUBB2B [axonemal microtubule]
TUBB2B [cytosol]
Inferred To
tubb2b [cytosol]
(Xenopus tropicalis)
Polyglutamyl-TUBB2B [cytosol]
(Mus musculus)
Polyglutamyl-TUBB2B [cytosol]
(Rattus norvegicus)
TUBB2B [cytosol]
(Sus scrofa)
Polyglutamyl-TUBB2A [cytosol]
(Dictyostelium discoideum)
Polyglutamyl-TUBB2A [cytosol]
(Plasmodium falciparum)
Modified Residues
Name
L-isoglutamyl-polyglutamic acid at unknown position
PsiMod Name
L-isoglutamyl-polyglutamic acid
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.
Cross References
RefSeq
NP_821080.1
OpenTargets
ENSG00000137285
GeneCards
Q9BVA1
HPA
ENSG00000137285-TUBB2B
Ensembl
ENSG00000137285
,
ENST00000259818
,
ENSP00000259818
PRO
Q9BVA1
Pharos - Targets
Q9BVA1
Orphanet
18462
PDB
6E7C
,
7ZCW
HMDB Protein
HMDBP08603
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54764 EPHA4
2
EPHA4 [plasma membrane]
(R-HSA-2682325)
p-Y596,Y602-EPHA4 [plasma membrane]
(R-HSA-3928352)
0.643
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
5
UniProt:Q8N0Z6 TTC5
3
TTC5 [nucleoplasm]
(R-HSA-6804264)
p-S203-TTC5 [nucleoplasm]
(R-HSA-6804261)
p-S203,S221-TTC5 [nucleoplasm]
(R-HSA-6804259)
0.527
3
UniProt:Q9HC35 EML4
12
EML4 [cytosol]
(R-HSA-9647741)
p-S,T-EML4 [cytosol]
(R-HSA-9648096)
EML4(1-496)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699812)
EML4(1-223)-ALK(1059-1620) fusion [cytosol]
(R-HSA-9699862)
EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol]
(R-HSA-9699813)
EML4(1-780)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9716113)
EML4(1-569)-p-7Y-ALK(1078-1620) fusion [cytosol]
(R-HSA-9716116)
EML4(1-223)-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9699903)
EML4(1-223)insKMSTREKNSQV-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9699885)
EML4(1-486)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699918)
EML4(1-569)-ALK(1078-1620) fusion [cytosol]
(R-HSA-9716112)
EML4(1-780)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9716119)
0.527
3
UniProt:P36404 ARL2
2
ARL2 [cytosol]
(R-HSA-5216230)
ARL2 [mitochondrial matrix]
(R-HSA-5250216)
0.527
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text