PICALM binds R-SNAREs

Stable Identifier
R-HSA-8867613
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PICALM is a phosphatidylinositol-binding clathrin assembly protein that interacts with PI(4,5)P2 and clathrin and plays a role in recruiting clathrin and AP-2 to nascent coated pits at the plasma membrane (Tebar et al, 1999). In addition, PICALM binds directly to a number of R-SNAREs, including VAMP2,3 and 8 to mediate their inclusion in clathrin-coated pits and subsequent recycling to the endosome where they function (Miller et al, 2011).

Literature References
PubMed ID Title Journal Year
10436022 Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic

Tebar, F, Bohlander, SK, Sorkin, A

Mol. Biol. Cell 1999
22118466 The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM

Miller, SE, Sahlender, DA, Graham, SC, Höning, S, Robinson, MS, Peden, AA, Owen, DJ

Cell 2011
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created