PICALM binds R-SNAREs

Stable Identifier
R-HSA-8867613
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PICALM is a phosphatidylinositol-binding clathrin assembly protein that interacts with PI(4,5)P2 and clathrin and plays a role in recruiting clathrin and AP-2 to nascent coated pits at the plasma membrane (Tebar et al, 1999). In addition, PICALM binds directly to a number of R-SNAREs, including VAMP2,3 and 8 to mediate their inclusion in clathrin-coated pits and subsequent recycling to the endosome where they function (Miller et al, 2011).

Participants
Participant Of
Orthologous Events