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PTPN3 [cytosol]
Stable Identifier
R-HSA-8867650
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tyrosine-protein phosphatase non-receptor type 3 ecNumber3.1.3.48/ecNumber, PTN3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
MAPK12 phosphorylates PTPN3 (Homo sapiens)
PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
PTPN3 [cytosol] (Homo sapiens)
PTPN3 binds p-T183,Y185 MAPK12 (Homo sapiens)
PTPN3 [cytosol] (Homo sapiens)
PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
PTPN3 [cytosol] (Homo sapiens)
PTPN3 dephosphorylates MAPK12 (Homo sapiens)
PTPN3 [cytosol] (Homo sapiens)
PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
PTPN3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P26045 PTPN3
Gene Names
PTPN3, PTPH1
Chain
chain:1-913
Reference Genes
BioGPS Gene:5774 PTPN3
COSMIC (genes):PTPN3 PTPN3
CTD Gene:5774 PTPN3
dbSNP Gene:5774 PTPN3
ENSEMBL:ENSG00000070159 PTPN3
HGNC:9655 PTPN3
KEGG Gene (Homo sapiens):5774 PTPN3
Monarch:5774 PTPN3
NCBI Gene:5774 PTPN3
OMIM:176877 PTPN3
UCSC:P26045 PTPN3
Reference Transcript
RefSeq:NM_002829.3 PTPN3
RefSeq:NM_001145370.1 PTPN3
RefSeq:XM_006717204.3 PTPN3
RefSeq:NM_001145368.1 PTPN3
RefSeq:XM_006717199.3 PTPN3
RefSeq:XM_011518889.2 PTPN3
RefSeq:XM_017014957.1 PTPN3
RefSeq:NM_001145369.1 PTPN3
RefSeq:XM_017014955.1 PTPN3
RefSeq:NM_001145371.1 PTPN3
Other Identifiers
0004150609
0106620484
11739618_a_at
11739619_a_at
11740363_a_at
11740364_a_at
11740367_a_at
11740368_s_at
11741134_a_at
1458_at
17097000
203997_at
227944_at
31885_at
3219887
3219888
3219889
3219890
3219891
3219892
3219893
3219894
3219895
3219896
3219897
3219898
3219900
3219902
3219903
3219904
3219913
3219914
3219915
3219916
3219917
3219918
3219920
3219923
3219924
3219927
3219928
3219929
3219932
3219933
3219934
3219937
3219939
3219940
3219941
3219942
3219943
3219944
3219954
3219955
3219958
3219959
3219966
43997_at
5774
8163149
A_23_P403898
A_24_P138091
A_24_P928969
GE578127
GE58036
GO:0000278
GO:0001784
GO:0003674
GO:0004721
GO:0004725
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005856
GO:0005886
GO:0006464
GO:0006470
GO:0006810
GO:0007049
GO:0007165
GO:0008092
GO:0008150
GO:0009056
GO:0009898
GO:0016020
GO:0016311
GO:0016787
GO:0016791
GO:0017080
GO:0019899
GO:0035335
GO:0042059
GO:0042592
GO:0043226
GO:0045930
GO:0048856
GO:0051045
GO:0051117
GO:0055085
GO:0097421
GO:0098902
GO:2000649
Hs.27004.0.A1_3p_at
ILMN_1717294
M64572_at
PH_hs_0024660
TC09001468.hg
TC09002738.hg
g4506292_3p_at
Participant Of
output
PTPN3 dephosphorylates MAPK12
hasComponent
PTPN3:p-T183,Y185-MAPK12 [cytosol]
input
PTPN3 binds p-T183,Y185 MAPK12
Other forms of this molecule
PTPN3 [plasma membrane]
p-S459 PTPN3 [cytosol]
Inferred To
ptp-1 [cytosol] (Caenorhabditis elegans)
Ptpmeg [cytosol] (Drosophila melanogaster)
sts [cytosol] (Xenopus tropicalis)
ptpn3 [cytosol] (Danio rerio)
Ptpn3 [cytosol] (Mus musculus)
Ptpn3 [cytosol] (Rattus norvegicus)
PTPN3 [cytosol] (Canis familiaris)
PTPN3 [cytosol] (Gallus gallus)
PTPN3 [cytosol] (Sus scrofa)
Cross References
RefSeq
XP_011517191.1
,
XP_006717267.1
,
NP_001138842.1
,
XP_016870446.1
,
XP_016870444.1
,
NP_001138840.1
,
NP_002820.3
,
XP_006717262.1
,
NP_001138841.1
,
NP_001138843.1
OpenTargets
ENSG00000070159
HPA
ENSG00000070159-PTPN3
ZINC - Substances
PTN3_HUMAN
GeneCards
P26045
ZINC target
P26045
Ensembl
ENST00000446349
,
ENSP00000416654
,
ENST00000374541
,
ENSG00000070159
,
ENST00000412145
,
ENSP00000395384
,
ENSP00000363667
PRO
P26045
Orphanet
22888
ZINC - Predictions - Purchasable
PTN3_HUMAN
HMDB Protein
HMDBP08935
PDB
4RH9
,
4QUM
,
4RI5
,
6HKS
,
4RH5
,
4S0G
,
4RI4
,
2B49
,
4QUN
,
4RHG
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.779
5
UniProt:Q04828 AKR1C1
1
AKR1C1 [cytosol]
(R-HSA-2855253)
0.718
6
UniProt:Q9NNW5 WDR6
0.718
6
UniProt:P25800 LMO1
1
LMO1 [nucleoplasm]
(R-HSA-8956514)
0.718
6
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.708
4
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.708
5
UniProt:P42566-1 EPS15
0.65
4
UniProt:P10912 GHR
7
GHR(257-638) [plasma membrane]
(R-HSA-1168803)
p-Y332,Y487,Y627-GHR(19-638) [plasma membrane]
(R-HSA-1169226)
p-5Y-GHR(19-638) [plasma membrane]
(R-HSA-1168904)
GHR(19-638) [endosome lumen]
(R-HSA-1169263)
GHR(19-256) [extracellular region]
(R-HSA-1168821)
GHR(19-638) [plasma membrane]
(R-HSA-982779)
GHR activated [plasma membrane]
(R-HSA-1168385)
0.645
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.597
3
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.597
3
UniProt:Q8TAA9 VANG1
0.558
3
UniProt:Q8NEK8 TET5D
0.556
3
UniProt:P40692 MLH1
3
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.556
3
UniProt:Q5GFL6-3 VWA2
0.556
3
UniProt:Q8TBK6 ZCH10
0.556
3
IntAct:EBI-16429620 CCSB ORF ID
0.556
3
UniProt:Q6ZRS2-3 SRCAP
0.556
3
UniProt:Q14689-6 DIP2A
0.556
3
UniProt:Q9NPJ8 NXT2
0.556
3
UniProt:Q8WV44 TRIM41
1
TRIM41 [cytosol]
(R-HSA-5688975)
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:Q01664 TFAP4
0.556
3
UniProt:Q96QG7 MTMR9
1
MTMR9 [cytosol]
(R-HSA-6809239)
0.556
3
UniProt:Q14524 SCN5A
1
SCN5A [plasma membrane]
(R-HSA-443382)
0.527
2
UniProt:P55072 VCP
8
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [cytosol]
(R-HSA-1181251)
0.524
2
UniProt:P06463 VE6
0.524
4
UniProt:P11473 VDR
2
VDR [nucleoplasm]
(R-HSA-375512)
SUMO2-VDR [nucleoplasm]
(R-HSA-4546376)
0.524
4
UniProt:P31040 SDHA
1
SDHA [mitochondrial inner membrane]
(R-HSA-70983)
0.499
2
UniProt:P23508 CRCM
0.499
2
UniProt:Q9ULK5 VANGL2
2
VANGL2 [plasma membrane]
(R-HSA-3965373)
pS5,S82,S84-VANGL2 [plasma membrane]
(R-HSA-4551547)
0.499
2
UniProt:Q9P2D3 HTR5B
0.462
2
UniProt:Q8TBC3 SHKB1
0.462
2
UniProt:Q14152 EIF3A
1
EIF3A [cytosol]
(R-HSA-72546)
0.462
2
UniProt:Q12906 ILF3
0.462
2
UniProt:Q9UQ35 SRRM2
1
SRRM2 [nucleoplasm]
(R-HSA-8865888)
0.462
2
UniProt:Q12905 ILF2
4
ILF2 [specific granule lumen]
(R-HSA-6799611)
ILF2 [ficolin-1-rich granule lumen]
(R-HSA-6801001)
ILF2 [extracellular region]
(R-HSA-6799684)
ILF2 [tertiary granule lumen]
(R-HSA-6800995)
0.462
2
UniProt:P55884 EIF3B
1
EIF3B [cytosol]
(R-HSA-72542)
0.462
2
UniProt:Q9UN30 SCML1
0.462
2
UniProt:Q9Y597 KCTD3
0.462
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.462
2
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