Reactome | PTPN3 [cytosol]

PTPN3 [cytosol]

Stable Identifier

R-HSA-8867650

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein phosphatase non-receptor type 3 ecNumber3.1.3.48/ecNumber, PTN3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P26045 PTPN3

Gene Names

PTPN3, PTPH1

Chain

chain:1-913

Reference Genes

BioGPS Gene:5774 PTPN3

COSMIC (genes):PTPN3 PTPN3

CTD Gene:5774 PTPN3

dbSNP Gene:5774 PTPN3

ENSEMBL:ENSG00000070159 PTPN3

HGNC:9655 PTPN3

KEGG Gene (Homo sapiens):5774 PTPN3

Monarch:5774 PTPN3

NCBI Gene:5774 PTPN3

OMIM:176877 PTPN3

UCSC:P26045 PTPN3

Reference Transcript

Other Identifiers

0004150609

0106620484

11739618_a_at

11739619_a_at

11740363_a_at

11740364_a_at

11740367_a_at

11740368_s_at

11741134_a_at

1458_at

17097000

203997_at

227944_at

31885_at

3219887

3219888

3219889

3219890

3219891

3219892

3219893

3219894

3219895

3219896

3219897

3219898

3219900

3219902

3219903

3219904

3219913

3219914

3219915

3219916

3219917

3219918

3219920

3219923

3219924

3219927

3219928

3219929

3219932

3219933

3219934

3219937

3219939

3219940

3219941

3219942

3219943

3219944

3219954

3219955

3219958

3219959

3219966

43997_at

5774

8163149

A_23_P403898

A_24_P138091

A_24_P928969

GE578127

GE58036

GO:0000278

GO:0001784

GO:0003674

GO:0004721

GO:0004725

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005856

GO:0005886

GO:0006464

GO:0006470

GO:0006810

GO:0007049

GO:0007165

GO:0008092

GO:0008150

GO:0009056

GO:0009898

GO:0016020

GO:0016311

GO:0016787

GO:0016791

GO:0017080

GO:0019899

GO:0035335

GO:0042059

GO:0042592

GO:0043226

GO:0045930

GO:0048856

GO:0051045

GO:0051117

GO:0055085

GO:0097421

GO:0098902

GO:2000649

Hs.27004.0.A1_3p_at

ILMN_1717294

M64572_at

PH_hs_0024660

TC09001468.hg

TC09002738.hg

g4506292_3p_at

Participant Of

output

PTPN3 dephosphorylates MAPK12

hasComponent

PTPN3:p-T183,Y185-MAPK12 [cytosol]

input

PTPN3 binds p-T183,Y185 MAPK12

Other forms of this molecule

PTPN3 [plasma membrane]

p-S459 PTPN3 [cytosol]

Inferred To

ptp-1 [cytosol] (Caenorhabditis elegans)

Ptpmeg [cytosol] (Drosophila melanogaster)

sts [cytosol] (Xenopus tropicalis)

ptpn3 [cytosol] (Danio rerio)

Ptpn3 [cytosol] (Mus musculus)

Ptpn3 [cytosol] (Rattus norvegicus)

PTPN3 [cytosol] (Canis familiaris)

PTPN3 [cytosol] (Gallus gallus)

PTPN3 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_011517191.1, XP_006717267.1, NP_001138842.1, XP_016870446.1, XP_016870444.1, NP_001138840.1, NP_002820.3, XP_006717262.1, NP_001138841.1, NP_001138843.1

OpenTargets

ENSG00000070159

HPA

ENSG00000070159-PTPN3

ZINC - Substances

PTN3_HUMAN

GeneCards

P26045

ZINC target

P26045

Ensembl

ENST00000446349, ENSP00000416654, ENST00000374541, ENSG00000070159, ENST00000412145, ENSP00000395384, ENSP00000363667

PRO

P26045

Orphanet

22888

ZINC - Predictions - Purchasable

PTN3_HUMAN

HMDB Protein

HMDBP08935

PDB

4RH9, 4QUM, 4RI5, 6HKS, 4RH5, 4S0G, 4RI4, 2B49, 4QUN, 4RHG

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.779	5
UniProt:Q04828 AKR1C1	1	AKR1C1 [cytosol] (R-HSA-2855253)	0.718	6
UniProt:Q9NNW5 WDR6			0.718	6
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.718	6
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.708	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.708	5
UniProt:P42566-1 EPS15			0.65	4
UniProt:P10912 GHR	7	GHR(257-638) [plasma membrane] (R-HSA-1168803) p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(19-638) [endosome lumen] (R-HSA-1169263) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR activated [plasma membrane] (R-HSA-1168385)	0.645	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.597	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.597	3
UniProt:Q8TAA9 VANG1			0.558	3
UniProt:Q8NEK8 TET5D			0.556	3
UniProt:P40692 MLH1	3	MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 [nucleoplasm] (R-HSA-912495)	0.556	3
UniProt:Q5GFL6-3 VWA2			0.556	3
UniProt:Q8TBK6 ZCH10			0.556	3
IntAct:EBI-16429620 CCSB ORF ID			0.556	3
UniProt:Q6ZRS2-3 SRCAP			0.556	3
UniProt:Q14689-6 DIP2A			0.556	3
UniProt:Q9NPJ8 NXT2			0.556	3
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:Q01664 TFAP4			0.556	3
UniProt:Q96QG7 MTMR9	1	MTMR9 [cytosol] (R-HSA-6809239)	0.556	3
UniProt:Q14524 SCN5A	1	SCN5A [plasma membrane] (R-HSA-443382)	0.527	2
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [cytosol] (R-HSA-1181251)	0.524	2
UniProt:P06463 VE6			0.524	4
UniProt:P11473 VDR	2	VDR [nucleoplasm] (R-HSA-375512) SUMO2-VDR [nucleoplasm] (R-HSA-4546376)	0.524	4
UniProt:P31040 SDHA	1	SDHA [mitochondrial inner membrane] (R-HSA-70983)	0.499	2
UniProt:P23508 CRCM			0.499	2
UniProt:Q9ULK5 VANGL2	2	VANGL2 [plasma membrane] (R-HSA-3965373) pS5,S82,S84-VANGL2 [plasma membrane] (R-HSA-4551547)	0.499	2
UniProt:Q9P2D3 HTR5B			0.462	2
UniProt:Q8TBC3 SHKB1			0.462	2
UniProt:Q14152 EIF3A	1	EIF3A [cytosol] (R-HSA-72546)	0.462	2
UniProt:Q12906 ILF3			0.462	2
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.462	2
UniProt:Q12905 ILF2	4	ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [tertiary granule lumen] (R-HSA-6800995)	0.462	2
UniProt:P55884 EIF3B	1	EIF3B [cytosol] (R-HSA-72542)	0.462	2
UniProt:Q9UN30 SCML1			0.462	2
UniProt:Q9Y597 KCTD3			0.462	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.462	2

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