CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

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R-HSA-8867756
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Reaction [binding]
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Homo sapiens
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CLASP proteins are recruited to nascent clathrin-coated pits (CCPs) through interactions with AP-2 and clathrin. Although in this pathway cargo recruitment is depicted as occuring after the recruitment of bulk AP-2 and clathrin, a number of studies suggest that they are largely recruited concomitantly (Liu et al, 2010; reviewed in McMahon and Boucrot, 2011). Concurrent interactions with sorting signals in cargo cytoplasmic tails and with clathrin and/or AP-2 ensure that CLASPs and cargo are incorporated into the emerging CCP (Schmid et al, 2006; Edeling et al, 2006; reviewed in Traub, 2009; Traub and Bonifacino, 2013; Kirchausen et al, 2014). In addition, incorporation of CLASPs and cargo may play a role in regulating the timing and dynamics of endocytosis (Loerke et al, 2009; Mettlen et al, 2009; Soohoo et al, 2013; Mettlen et al, 2010; Puthenveedu et al, 2005).

Literature References
PubMed ID Title Journal Year
19458185 Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits

Mettlen, M, Stoeber, M, Loerke, D, Antonescu, CN, Danuser, G, Schmid, SL

Mol. Biol. Cell 2009
16516836 Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly

Edeling, MA, Mishra, SK, Keyel, PA, Steinhauser, AL, Collins, BM, Roth, R, Heuser, JE, Owen, DJ, Traub, LM

Dev. Cell 2006
21779028 Molecular mechanism and physiological functions of clathrin-mediated endocytosis

McMahon, HT, Boucrot, E

Nat. Rev. Mol. Cell Biol. 2011
21187331 Local clustering of transferrin receptors promotes clathrin-coated pit initiation

Liu, AP, Aguet, F, Danuser, G, Schmid, SL

J. Cell Biol. 2010
24789820 Molecular structure, function, and dynamics of clathrin-mediated membrane traffic

Kirchhausen, T, Owen, D, Harrison, SC

Cold Spring Harb Perspect Biol 2014
19296720 Cargo and dynamin regulate clathrin-coated pit maturation

Loerke, D, Mettlen, M, Yarar, D, Jaqaman, K, Jaqaman, H, Danuser, G, Schmid, SL

PLoS Biol. 2009
24186068 Cargo recognition in clathrin-mediated endocytosis

Traub, LM, Bonifacino, JS

Cold Spring Harb Perspect Biol 2013
17018281 Cargo regulates clathrin-coated pit dynamics

Puthenveedu, MA, von Zastrow, M

Cell 2006
19696796 Tickets to ride: selecting cargo for clathrin-regulated internalization

Traub, LM

Nat. Rev. Mol. Cell Biol. 2009
20231386 Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis

Mettlen, M, Loerke, D, Yarar, D, Danuser, G, Schmid, SL

J. Cell Biol. 2010
16903783 Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly

Schmid, EM, Ford, MG, Burtey, A, Praefcke, GJ, Peak-Chew, SY, Mills, IG, Benmerah, A, McMahon, HT

PLoS Biol. 2006
23536704 Divergent modes for cargo-mediated control of clathrin-coated pit dynamics

Soohoo, AL, Puthenveedu, MA

Mol. Biol. Cell 2013
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