Reactome | PRPF40A [nucleoplasm]

PRPF40A [nucleoplasm]

Stable Identifier

R-HSA-8867890

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Pre-mRNA-processing factor 40 homolog A, PR40A_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75400 PRPF40A

Gene Names

PRPF40A, FBP11, FLAF1, FNBP3, HIP10, HYPA, HSPC225

Chain

chain:1-957

Reference Genes

BioGPS Gene:55660 PRPF40A

COSMIC (genes):PRPF40A PRPF40A

CTD Gene:55660 PRPF40A

dbSNP Gene:55660 PRPF40A

ENSEMBL:ENSG00000196504 PRPF40A

HGNC:16463 PRPF40A

KEGG Gene (Homo sapiens):55660 PRPF40A

Monarch:55660 PRPF40A

NCBI Gene:55660 PRPF40A

OMIM:612941 PRPF40A

UCSC:O75400 PRPF40A

Reference Transcript

RefSeq:NM_017892.3 PRPF40A

Participant Of

input

Formation of the Spliceosomal E complex

hasComponent

output

Formation of the Spliceosomal B Complex

Inferred To

ipo5 [nucleoplasm] (Xenopus tropicalis)

prpf40a [nucleoplasm] (Danio rerio)

PRPF40A [nucleoplasm] (Caenorhabditis elegans)

PRPF40A [nucleoplasm] (Canis familiaris)

PRPF40A [nucleoplasm] (Gallus gallus)

PRPF40A [nucleoplasm] (Sus scrofa)

Prp40 [nucleoplasm] (Drosophila melanogaster)

Prpf40a [nucleoplasm] (Mus musculus)

Prpf40a [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_060362.3

OpenTargets

ENSG00000196504

HPA

ENSG00000196504-PRPF40A

GeneCards

O75400

PRO

O75400

PDB

2L5F, 2CQN, 1YWJ, 1ZR7, 2DYF, 1YWI, 2LKS, 2KZG, 2L9V, 1UZC

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.743	15
UniProt:Q9NRR5 UBQL4			0.553	2
UniProt:Q9H190 SDCB2			0.553	2
UniProt:Q9BUJ2 HNRNPUL1	1	HNRNPUL1 [nucleoplasm] (R-HSA-72106)	0.553	2
UniProt:Q53F19 NCBP3			0.527	2
UniProt:Q8N5F7 NKAP			0.508	2
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.508	2
UniProt:Q12873 CHD3	2	SUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372) CHD3 [nucleoplasm] (R-HSA-4657012)	0.508	2
UniProt:Q15637 SF1	1	SF1 [nucleoplasm] (R-HSA-8865928)	0.482	3

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