Reactome | PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

Stable Identifier

R-HSA-8868066

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

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Plasma membrane enrichment of PI(4,5)P2 is maintained in part through the action of PI 4 phosphatase 5 kinases (PIPKIs) such as PIP5K1C (Di Paolo and De Camilli, 2006). PIP5K1C interacts directly with AP-2 and the interaction activates the kinase, generating a positive feedback loop for the recruitment of AP-2 to the plasma membrane (Krauss et al, 2006; Bairstow et al, 2006; Thieman et al, 2009; reviewed in Daumke et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
24581490	BAR domain scaffolds in dynamin-mediated membrane fission Daumke, O, Haucke, V, Roux, A	Cell	2014
16707488	Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis Ling, K, Carbonara, C, Firestone, AJ, Bairstow, SF, Anderson, RA, Su, X	J. Biol. Chem.	2006
19287005	Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendage Ling, K, Mishra, SK, Thieman, JR, Traub, LM, Anderson, RA, Doray, B	J. Biol. Chem.	2009
17035995	Phosphoinositides in cell regulation and membrane dynamics Di Paolo, G, De Camilli, P	Nature	2006
16880396	Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes Kukhtina, V, Haucke, V, Pechstein, A, Krauss, M	Proc. Natl. Acad. Sci. U.S.A.	2006