PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

Stable Identifier
R-HSA-8868066
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Plasma membrane enrichment of PI(4,5)P2 is maintained in part through the action of PI 4 phosphatase 5 kinases (PIPKIs) such as PIP5K1C (Di Paolo and De Camilli, 2006). PIP5K1C interacts directly with AP-2 and the interaction activates the kinase, generating a positive feedback loop for the recruitment of AP-2 to the plasma membrane (Krauss et al, 2006; Bairstow et al, 2006; Thieman et al, 2009; reviewed in Daumke et al, 2014).

Literature References
PubMed ID Title Journal Year
16707488 Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis

Bairstow, SF, Ling, K, Su, X, Firestone, AJ, Carbonara, C, Anderson, RA

J. Biol. Chem. 2006
24581490 BAR domain scaffolds in dynamin-mediated membrane fission

Daumke, O, Roux, A, Haucke, V

Cell 2014
19287005 Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendage

Thieman, JR, Mishra, SK, Ling, K, Doray, B, Anderson, RA, Traub, LM

J. Biol. Chem. 2009
17035995 Phosphoinositides in cell regulation and membrane dynamics

Di Paolo, G, De Camilli, P

Nature 2006
16880396 Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes

Krauss, M, Kukhtina, V, Pechstein, A, Haucke, V

Proc. Natl. Acad. Sci. U.S.A. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
1-phosphatidylinositol-4-phosphate 5-kinase activity of PIP5K1C [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed