PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

Stable Identifier
R-HSA-8868066
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Plasma membrane enrichment of PI(4,5)P2 is maintained in part through the action of PI 4 phosphatase 5 kinases (PIPKIs) such as PIP5K1C (Di Paolo and De Camilli, 2006). PIP5K1C interacts directly with AP-2 and the interaction activates the kinase, generating a positive feedback loop for the recruitment of AP-2 to the plasma membrane (Krauss et al, 2006; Bairstow et al, 2006; Thieman et al, 2009; reviewed in Daumke et al, 2014).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
1-phosphatidylinositol-4-phosphate 5-kinase activity of PIP5K1C [cytosol]
Physical Entity
Activity
Orthologous Events