Reactome: A Curated Pathway Database

Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2

Stable Identifier
R-HSA-8868072
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Clathrin-associated PIK3C2A catalyzes the conversion of PI(4)P to PI(3,4)P2, which contributes to the recruitment of BAR domain proteins such as SNX9 to the clathrin-coated pit (Domin et al, 2000; Gaidarov et al, 2001; Gaidarov et al, 2005; Posor et al, 2013; reviewed in Daumke et al, 2014).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
1-phosphatidylinositol-4-phosphate 3-kinase activity of PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] 1-phosphatidylinositol-4-phosphate 3-kinase activity (0035005)
Orthologous Events