Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2

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R-HSA-8868072
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Reaction [transition]
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Homo sapiens
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Clathrin-associated PIK3C2A catalyzes the conversion of PI(4)P to PI(3,4)P2, which contributes to the recruitment of BAR domain proteins such as SNX9 to the clathrin-coated pit (Domin et al, 2000; Gaidarov et al, 2001; Gaidarov et al, 2005; Posor et al, 2013; reviewed in Daumke et al, 2014).

Literature References
PubMed ID Title Journal Year
11239472 The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking

Gaidarov, I, Smith, ME, Domin, J, Keen, JH

Mol. Cell 2001
16215232 Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function

Gaidarov, I, Zhao, Y, Keen, JH

J. Biol. Chem. 2005
10766823 The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles

Domin, J, Gaidarov, I, Smith, ME, Keen, JH, Waterfield, MD

J Biol Chem 2000
24581490 BAR domain scaffolds in dynamin-mediated membrane fission

Daumke, O, Roux, A, Haucke, V

Cell 2014
23823722 Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

Posor, Y, Eichhorn-Gruenig, M, Puchkov, D, Schöneberg, J, Ullrich, A, Lampe, A, Müller, R, Zarbakhsh, S, Gulluni, F, Hirsch, E, Krauss, M, Schultz, C, Schmoranzer, J, Noé, F, Haucke, V

Nature 2013
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Title
1-phosphatidylinositol-4-phosphate 3-kinase activity of PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane]
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