Reactome: A Curated Pathway Database

CAST binds Ca2+ bound calpain

Stable Identifier
R-HSA-8868134
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The proteolytic activity of calpain complexes is inhibited by binding to calpastatin (CAST) (Takano et al. 1995). Based on detailed structural studies of recombinant rat proteins, CAST associates with calcium-bound calpain heterodimers and occupies both sides of the calpain active site cleft (Hanna et al. 2008). CAST levels are reduced in Alzheimer disease (Sato et al. 2011).

Literature References
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