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CDK5:p25 phosphorylates lamin B1

Stable Identifier
R-HSA-8868340
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Alzheimer's disease (AD), like many other neurodegenerative diseases, is characterized by nuclear envelope fragmentation. Based on a mouse AD model, nuclear fragmentation is initiated by phosphorylation of nuclear lamins by p25-activated CDK5. The CDK5:p25 complex phosphorylates lamin B1 (LMNB1) at serine residues S23 and S393. Nuclear envelope fragmentation increases access of the CDK5:p25 complex to nuclear proteins and precedes neuronal death (Chang et al. 2011).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of CDK5:p25 [nucleoplasm]
Physical Entity
Activity
Inferred From
Disease
Name Identifier Synonyms
Alzheimer's disease 10652 AD, Alzheimers dementia, Alzheimer disease