CDK5:p25 phosphorylates lamin A

Stable Identifier
R-HSA-8868344
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Alzheimer's disease (AD), like many other neurodegenerative diseases, is characterized by nuclear envelope fragmentation. Based on a mouse AD model, nuclear fragmentation is initiated by phosphorylation of nuclear lamins by p25-activated CDK5. The CDK5:p25 complex phosphorylates lamin A (LMNA-1) at serine residues S22 and S392, with S392 being the major CDK5 target site. Nuclear envelope fragmentation increases access of the CDK5:p25 complex to nuclear proteins and precedes neuronal death (Chang et al. 2011).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of CDK5:p25 [nucleoplasm]
Physical Entity
Activity
Inferred From
Disease
Name Identifier Synonyms
Alzheimer's disease 10652 AD, Alzheimers dementia, Alzheimer disease