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p-T90-PRDX1 [cytosol]
Stable Identifier
R-HSA-8868564
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CDK5:p25 phosphorylates PRDX1 (Homo sapiens)
p-T90-PRDX1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q06830 PRDX1
Gene Names
PRDX1, PAGA, PAGB, TDPX2
Chain
initiator methionine:1, chain:2-199
Reference Genes
BioGPS Gene:5052 PRDX1
COSMIC (genes):PRDX1 PRDX1
CTD Gene:5052 PRDX1
dbSNP Gene:5052 PRDX1
ENSEMBL:ENSG00000117450 PRDX1
HGNC:9352 PRDX1
KEGG Gene (Homo sapiens):5052 PRDX1
Monarch:5052 PRDX1
NCBI Gene:5052 PRDX1
OMIM:176763 PRDX1
UCSC:Q06830 PRDX1
Reference Transcript
RefSeq:NM_181697.2 PRDX1
RefSeq:NM_002574.3 PRDX1
RefSeq:NM_001202431.1 PRDX1
RefSeq:NM_181696.2 PRDX1
Other Identifiers
0004070072
11742924_a_at
16686472
208680_at
2410243
2410244
2410245
2410246
2410247
2410248
2410249
2410250
2410252
2410253
3198940
41213_at
5052
7915733
A_23_P11995
A_33_P3377199
GE62148
GO:0000302
GO:0001501
GO:0001895
GO:0002376
GO:0003674
GO:0003723
GO:0004601
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0006464
GO:0006950
GO:0006979
GO:0007165
GO:0008150
GO:0008283
GO:0008379
GO:0009056
GO:0016209
GO:0016491
GO:0019430
GO:0030101
GO:0031410
GO:0032872
GO:0034101
GO:0034599
GO:0042267
GO:0042470
GO:0042592
GO:0042744
GO:0042802
GO:0043226
GO:0045296
GO:0045321
GO:0045454
GO:0048856
GO:0051186
GO:0051920
GO:0055114
GO:0070062
GO:1901222
ILMN_1710159
ILMN_2366388
ILMN_2366391
PH_hs_0029347
TC01002611.hg
X67951_at
g440305_3p_s_at
Participant Of
output
CDK5:p25 phosphorylates PRDX1
Other forms of this molecule
PRDX1 [cytosol]
HOOS-C52-PRDX1 [cytosol]
Modified Residues
Name
O-phospho-L-threonine at 90
Coordinate
90
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_002565.1
,
NP_859047.1
,
NP_859048.1
,
NP_001189360.1
Target Pathogen
5b354852be737e166372e8a8
OpenTargets
ENSG00000117450
IntEnz
1.11.1.24
GeneCards
Q06830
HPA
ENSG00000117450-PRDX1
Ensembl
ENST00000319248
,
ENST00000262746
,
ENSG00000117450
,
ENSP00000262746
,
ENSP00000361152
PRO
Q06830
Orphanet
28750
PDB
3HY2
,
4XCS
,
2RII
HMDB Protein
HMDBP02990
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13043 STK4
4
p-T183-STK4(1-487) [cytosol]
(R-HSA-2028258)
p-T183-STK4(1-326) [cytosol]
(R-HSA-2028682)
STK4(327-487) [cytosol]
(R-HSA-2028668)
STK4(1-487) [cytosol]
(R-HSA-201627)
0.66
11
UniProt:P60484 PTEN
122
PTEN [nucleoplasm]
(R-HSA-5690148)
K48polyUb-PTEN [cytosol]
(R-HSA-8874327)
PolyUb-PTEN [nucleoplasm]
(R-HSA-6782515)
PTEN H93R [cytosol]
(R-HSA-2318524)
PTEN C124R [cytosol]
(R-HSA-2317439)
PTEN H93Y [cytosol]
(R-HSA-2318520)
PTEN R130G [cytosol]
(R-HSA-2317339)
PTEN H93D [cytosol]
(R-HSA-2318550)
PTEN R130L [cytosol]
(R-HSA-2317430)
PTEN H93A [cytosol]
(R-HSA-2318544)
PTEN G129E [cytosol]
(R-HSA-2318509)
PTEN S170N [cytosol]
(R-HSA-2318408)
PTEN R173P [cytosol]
(R-HSA-2317480)
PTEN R130Q [cytosol]
(R-HSA-2317416)
PTEN H93Q [cytosol]
(R-HSA-2318565)
PTEN G129R [cytosol]
(R-HSA-2318501)
PTEN H123Y [cytosol]
(R-HSA-2318469)
PTEN S170R [cytosol]
(R-HSA-2318437)
PTEN R173C [cytosol]
(R-HSA-2317478)
PTEN R173H [cytosol]
(R-HSA-2317473)
PTEN C124S [cytosol]
(R-HSA-2317379)
PTEN C124Y [cytosol]
(R-HSA-2317464)
PTEN R130P [cytosol]
(R-HSA-2317432)
PTEN C124F [cytosol]
(R-HSA-2317461)
PTEN G129V [cytosol]
(R-HSA-2318503)
PTEN S170I [cytosol]
(R-HSA-2318455)
PTEN S170G [cytosol]
(R-HSA-2318465)
PTEN E99* [cytosol]
(R-HSA-9659052)
PTEN G165* [cytosol]
(R-HSA-9659117)
PTEN E157* [cytosol]
(R-HSA-9658926)
PTEN E150* [cytosol]
(R-HSA-9658920)
PTEN E43* [cytosol]
(R-HSA-9659049)
PTEN Q17* [cytosol]
(R-HSA-9659305)
PTEN E91* [cytosol]
(R-HSA-9659050)
PTEN S59* [cytosol]
(R-HSA-9659360)
PTEN E114* [cytosol]
(R-HSA-9658915)
PTEN L139* [cytosol]
(R-HSA-9659196)
PTEN Y176* [cytosol]
(R-HSA-9659389)
PTEN Y177* [cytosol]
(R-HSA-9659390)
PTEN Q149* [cytosol]
(R-HSA-9659320)
PTEN L146* [cytosol]
(R-HSA-9659193)
PTEN G20* [cytosol]
(R-HSA-9659129)
PTEN G127* [cytosol]
(R-HSA-9659130)
PTEN Y46* [cytosol]
(R-HSA-9659387)
PTEN L182* [cytosol]
(R-HSA-9659189)
PTEN Q97* [cytosol]
(R-HSA-9659318)
PTEN Q171* [cytosol]
(R-HSA-9659312)
PTEN G129* [cytosol]
(R-HSA-9659120)
PTEN E18* [cytosol]
(R-HSA-9658931)
PTEN Y180* [cytosol]
(R-HSA-9659404)
PTEN K163* [cytosol]
(R-HSA-9659148)
PTEN Y27* [cytosol]
(R-HSA-9659405)
PTEN Y65* [cytosol]
(R-HSA-9659406)
PTEN Y68* [cytosol]
(R-HSA-9659400)
PTEN K128* [cytosol]
(R-HSA-9659145)
PTEN Y138* [cytosol]
(R-HSA-9659402)
PTEN K125* [cytosol]
(R-HSA-9659147)
PTEN Y88* [cytosol]
(R-HSA-9659399)
PTEN Q110* [cytosol]
(R-HSA-9659328)
PTEN L23* [cytosol]
(R-HSA-9659201)
PTEN E7* [cytosol]
(R-HSA-9659036)
PTEN C105* [cytosol]
(R-HSA-9658911)
PTEN E73* [cytosol]
(R-HSA-9659039)
PTEN K62* [cytosol]
(R-HSA-9659160)
PTEN E40* [cytosol]
(R-HSA-9659032)
PTEN Y178* [cytosol]
(R-HSA-9659417)
PTEN R130* [cytosol]
(R-HSA-2318571)
PTEN W111* [cytosol]
(R-HSA-9659414)
PTEN R11* [cytosol]
(R-HSA-9659350)
PTEN K13* [cytosol]
(R-HSA-9659152)
PTEN Y174* [cytosol]
(R-HSA-9659409)
PTEN K147* [cytosol]
(R-HSA-9659153)
PTEN R84* [cytosol]
(R-HSA-9659347)
PTEN G293* [cytosol]
(R-HSA-9659113)
PTEN S287* [cytosol]
(R-HSA-9659371)
PTEN Q214* [cytosol]
(R-HSA-9659307)
PTEN S229* [cytosol]
(R-HSA-9659366)
PTEN Q219* [cytosol]
(R-HSA-9659302)
PTEN Q261* [cytosol]
(R-HSA-9659303)
PTEN E299* [cytosol]
(R-HSA-9659040)
PTEN Y336* [cytosol]
(R-HSA-9659388)
PTEN Q245* [cytosol]
(R-HSA-9659326)
PTEN Y225* [cytosol]
(R-HSA-9659391)
PTEN Y240* [cytosol]
(R-HSA-9659385)
PTEN C218* [cytosol]
(R-HSA-9659065)
PTEN C250* [cytosol]
(R-HSA-9659066)
PTEN L247* [cytosol]
(R-HSA-9659195)
PTEN G209* [cytosol]
(R-HSA-9659124)
PTEN C211* [cytosol]
(R-HSA-9659062)
PTEN G230* [cytosol]
(R-HSA-9659121)
PTEN Q298* [cytosol]
(R-HSA-9659314)
PTEN L320* [cytosol]
(R-HSA-9659187)
PTEN E242* [cytosol]
(R-HSA-9659084)
PTEN K332* [cytosol]
(R-HSA-9659151)
PTEN E284* [cytosol]
(R-HSA-9659087)
PTEN E291* [cytosol]
(R-HSA-9659081)
PTEN K330* [cytosol]
(R-HSA-9659146)
PTEN E314* [cytosol]
(R-HSA-9659078)
PTEN Y346* [cytosol]
(R-HSA-9659392)
PTEN C296* [cytosol]
(R-HSA-9659072)
PTEN W274* [cytosol]
(R-HSA-9659393)
PTEN R233* [cytosol]
(R-HSA-2318573)
PTEN R335* [cytosol]
(R-HSA-2318568)
PTEN E256* [cytosol]
(R-HSA-9659098)
PTEN R189* [cytosol]
(R-HSA-9659354)
PTEN E307* [cytosol]
(R-HSA-9659099)
PTEN K263* [cytosol]
(R-HSA-9659156)
PTEN E235* [cytosol]
(R-HSA-9659029)
PTEN E288* [cytosol]
(R-HSA-9659094)
PTEN K221* [cytosol]
(R-HSA-9659158)
PTEN K344* [cytosol]
(R-HSA-9659159)
K27polyUb-PTEN [cytosol]
(R-HSA-8851009)
p-3S,2T-PTEN [cytosol]
(R-HSA-8850936)
p-Y336-PTEN [cytosol]
(R-HSA-8847980)
PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol]
(R-HSA-8948841)
RibC-E40,E150,D326-PTEN [cytosol]
(R-HSA-8948798)
PTEN [cytosol]
(R-HSA-199420)
PTEN [nucleoplasm]
(R-HSA-6807273)
MonoUb-K13,K289-PTEN [nucleoplasm]
(R-HSA-6807264)
MonoUb-K13,K289-PTEN [cytosol]
(R-HSA-6807247)
K48polyUb-K289-PTEN [cytosol]
(R-HSA-8948777)
PolyUb-PTEN [cytosol]
(R-HSA-6807280)
0.632
7
UniProt:Q9BYN0 SRXN1
0.618
3
UniProt:P13693 TCTP
0.567
4
UniProt:Q8N7X4 MAGB6
0.556
3
UniProt:Q86TI2-2 Q86TI22
0.556
3
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.553
2
UniProt:P10275 AR
4
SUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
AR [cytosol]
(R-HSA-5618082)
AR [nucleoplasm]
(R-HSA-446174)
0.544
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P54274 TERF1
1
TERF1 [nucleoplasm]
(R-HSA-164618)
0.508
2
UniProt:P04156 PRNP
2
PRNP [plasma membrane]
(R-HSA-375060)
PRNP [cytosol]
(R-HSA-9617597)
0.499
4
UniProt:Q00005 2ABB
0.462
2
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