Reactome | p-T90-PRDX1 [cytosol]

p-T90-PRDX1 [cytosol]

Stable Identifier

R-HSA-8868564

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of programmed cell death (Homo sapiens)
  - Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Neurodegenerative Diseases (Homo sapiens)
      - Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
        
        CDK5:p25 phosphorylates PRDX1 (Homo sapiens)
        
        p-T90-PRDX1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q06830 PRDX1

Gene Names

PRDX1, PAGA, PAGB, TDPX2

Chain

initiator methionine:1, chain:2-199

Reference Genes

BioGPS Gene:5052 PRDX1

COSMIC (genes):PRDX1 PRDX1

CTD Gene:5052 PRDX1

dbSNP Gene:5052 PRDX1

ENSEMBL:ENSG00000117450.15 PRDX1

HGNC:9352 PRDX1

KEGG Gene (Homo sapiens):5052 PRDX1

Monarch:5052 PRDX1

NCBI Gene:5052 PRDX1

OMIM:176763 PRDX1

UCSC:Q06830 PRDX1

Reference Transcript

Other Identifiers

0004070072

11742924_a_at

16686472

208680_PM_at

208680_at

2410243

2410244

2410245

2410246

2410247

2410248

2410249

2410250

2410252

2410253

2410254

3198940

41213_at

5052

7915733

A_23_P11995

A_33_P3377199

GO:0000302

GO:0001501

GO:0001895

GO:0002376

GO:0003723

GO:0004601

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0006979

GO:0008283

GO:0008379

GO:0016209

GO:0016491

GO:0019430

GO:0023052

GO:0030101

GO:0031410

GO:0032872

GO:0034101

GO:0042267

GO:0042470

GO:0042744

GO:0042802

GO:0043226

GO:0045296

GO:0045321

GO:0045454

GO:0048144

GO:0048856

GO:0051920

GO:0062197

GO:0070062

GO:0098542

GO:0098754

GO:0098869

GO:0140824

GO:1901222

HMNXSV003001899

ILMN_1710159

ILMN_2366388

ILMN_2366391

PH_hs_0029347

TC01002611.hg

X67951_at

g440305_3p_s_at

Participates

as an output of

CDK5:p25 phosphorylates PRDX1 (Homo sapiens)

Other forms of this molecule

PRDX1 [cytosol]

HOOS-C52-PRDX1 [cytosol]

Modified Residues

Name

O-phospho-L-threonine at 90

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_002565.1, NP_859047.1, NP_001189360.1, NP_859048.1

OpenTargets

ENSG00000117450

IntEnz

1.11.1.24

HPA

ENSG00000117450-PRDX1

GeneCards

Q06830

Ensembl

ENST00000676549, ENSP00000262746, ENST00000424390, ENST00000447184, ENSP00000389047, ENSG00000117450, ENSP00000407034, ENST00000262746, ENSP00000503140, ENST00000319248, ENSP00000361152

PRO

Q06830

Pharos - Targets

Q06830

Orphanet

28750

HMDB Protein

HMDBP02990

PDB

2RII, 4XCS, 7LJ1, 3HY2

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682)	0.66	11
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.632	7
UniProt:Q9BYN0 SRXN1	1	SRXN1 [endoplasmic reticulum membrane] (R-HSA-9759366)	0.618	3
UniProt:P13693 TCTP			0.567	4
UniProt:Q8N7X4 MAGB6			0.556	3
UniProt:Q86TI2-2 Q86TI22			0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174)	0.544	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P54274 TERF1	1	TERF1 [nucleoplasm] (R-HSA-164618)	0.508	2
UniProt:P04156 PRNP	2	PRNP [cytosol] (R-HSA-9617597) PRNP [plasma membrane] (R-HSA-375060)	0.499	4
UniProt:Q00005 2ABB			0.462	2

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