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CDK5:p25 phosphorylates PRDX1

Stable Identifier
R-HSA-8868567
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Oxidative stress, manifested through accumulation of reactive oxygen species in the cell, is one of the hallmarks of Alzheimer's disease. Based on mouse model studies, CDK5, aberrantly activated by binding to p25, phosphorylates the peroxide reductase PRDX1 on a conserved threonine residue T90, thus inactivating it and contributing to ROS accumulation (Sun et al. 2008).

Literature References
PubMed ID Title Journal Year
18691386 Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction J. Neurochem. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of CDK5:p25 [cytosol]
Physical Entity
Activity
Inferred From
Disease
Name Identifier Synonyms
Alzheimer's disease 10652 AD, Alzheimers dementia, Alzheimer disease