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GAK
Stable Identifier
R-HSA-8868619
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cyclin-G-associated kinase ecNumber2.7.11.1/ecNumber, GAK_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
GAK [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
GAK [cytosol] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
GAK [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
GAK [cytosol] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
GAK [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
GAK [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
GAK [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
GAK [cytosol] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
GAK [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
GAK [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
GAK,DNAJC6 [cytosol] (Homo sapiens)
GAK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14976 GAK
Gene Names
GAK
Chain
initiator methionine:1, chain:2-1311
Reference Genes
BioGPS Gene:2580 GAK
COSMIC (genes):GAK GAK
CTD Gene:2580 GAK
dbSNP Gene:2580 GAK
ENSEMBL:ENSG00000178950 GAK
HGNC:4113 GAK
KEGG Gene (Homo sapiens):hsa:2580 GAK
Monarch:2580 GAK
NCBI Gene:2580 GAK
OMIM:602052 GAK
UCSC:O14976 GAK
Reference Transcript
RefSeq:NM_001318134.1 GAK
RefSeq:NM_005255.3 GAK
Other Identifiers
0004280239
11721027_a_at
11754278_x_at
16973375
202281_at
2580
27405
27459
27463
2756674
2756675
2756676
2756677
2756678
2756679
2756682
2756684
2756685
2756693
2756694
2756696
2756697
2756699
2756700
2756701
2756702
2756705
2756711
2756713
2756714
2756724
2756725
2756726
2756728
2756731
2756737
2756739
2756743
2756746
2756747
2756757
2756759
2756765
2756766
2756767
2756770
2756771
2756776
2756777
40225_at
4C57
4C58
4C59
4O38
4Y8D
8098789
A_23_P155700
A_24_P397150
CCDS3340
CCDS82902
D6RE78
ENSG00000178950
ENSP00000314499
ENSP00000421361
ENST00000314167
ENST00000511163
EntrezGene:2580
g4885250_3p_s_at
GAK
GAK-201
GAK-214
GE57429
GO:0000166
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005794
GO:0005829
GO:0005925
GO:0006468
GO:0006898
GO:0007029
GO:0007030
GO:0007049
GO:0010977
GO:0016020
GO:0016191
GO:0016301
GO:0016310
GO:0016740
GO:0030054
GO:0030332
GO:0031982
GO:0043231
GO:0045202
GO:0048471
GO:0051085
GO:0051087
GO:0061024
GO:0072318
GO:0072583
GO:0072600
GO:0090002
GO:0090160
GO:1905224
HGNC:4113
HPA027405
HPA027459
HPA027463
Hs.369607
ILMN_1813775
MIM:602052
NM_001318134
NM_005255
NP_001305063
NP_005246
PF00069
PF10409
PH_hs_0009213
SM00220
SM00271
SM01326
TC04000957.hg
uc003gbm.6
uc003gbn.6
UPI000012B04A
UPI000020B996
XM_005272268
XM_005272270
XM_011513425
XM_011513426
XM_011513427
XM_011513428
XM_011513429
XM_011513430
XM_011513431
XM_011513432
XM_011513434
XM_017007991
XM_017007992
XM_017007993
XM_017007994
XM_017007995
XP_005272325
XP_005272327
XP_011511727
XP_011511728
XP_011511729
XP_011511730
XP_011511731
XP_011511732
XP_011511733
XP_011511734
XP_011511736
XP_016863480
XP_016863481
XP_016863482
XP_016863483
XP_016863484
Participant Of
hasMember
GAK,DNAJC6 [cytosol]
Other forms of this molecule
GAK [Golgi membrane]
GAK [cytoplasmic vesicle membrane]
Inferred To
GAK [cytosol] (Bos taurus)
GAK [cytosol] (Caenorhabditis elegans)
GAK [cytosol] (Canis familiaris)
GAK [cytosol] (Danio rerio)
GAK [cytosol] (Drosophila melanogaster)
GAK [cytosol] (Gallus gallus)
GAK [cytosol] (Mus musculus)
GAK [cytosol] (Rattus norvegicus)
GAK [cytosol] (Sus scrofa)
GAK [cytosol] (Taeniopygia guttata)
GAK [cytosol] (Xenopus tropicalis)
Homologues of GAK [cytosol] (Caenorhabditis elegans)
Homologues of GAK [cytosol] (Danio rerio)
Homologues of GAK [cytosol] (Drosophila melanogaster)
Homologues of GAK [cytosol] (Mus musculus)
Cross References
RefSeq
NP_005246.2
,
NP_001305063.1
ZINC - World Drugs
GAK_HUMAN
Brenda
2.7.11.1
ZINC - FDA approved
GAK_HUMAN
ZINC - Substances
GAK_HUMAN
GeneCards
O14976
DOCK Blaster
4Y8D
,
4O38
,
4C57
,
4C58
,
4C59
ZINC target
O14976
PRO
O14976
ZINC - Predictions - Purchasable
GAK_HUMAN
HMDB Protein
HMDBP09468
PDB
4C58
,
4C59
,
4O38
,
4Y8D
,
4C57
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.725
10
UniProt:Q9NQ11 ATP13A2
1
ATP13A2 [lysosomal lumen]
(R-HSA-939762)
0.508
2
UniProt:P11142 HSPA8
8
HSPA8 [cytosol]
(R-HSA-264476)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
0.499
5
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