SYNJ hydrolyze PI(4,5)P2 to PI(4)P

Stable Identifier
R-HSA-8868648
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Inositol-5-phosphatases like SYNJs and OCRL hydrolyze PI(4,5)P2 to PI(4)P. In the context of CME, this promotes the abortive turnover (disassembly) of some CCPs, contributes to the dynamin-mediated scission of the clathrin-coated vesicle neck, and promotes clathrin uncoating following scission (Guan et al, 2010; Cremona et al, 1999; Mani et al, 2007; Chang-Ileto et al, 2011; Antonescu et al, 2011; reviewed in McMahon and Boucrot, 2011; Daumke et al, 2014).

Literature References
PubMed ID Title Journal Year
21779028 Molecular mechanism and physiological functions of clathrin-mediated endocytosis

McMahon, HT, Boucrot, E

Nat. Rev. Mol. Cell Biol. 2011
18093523 The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals

Mani, M, Lee, SY, Lucast, L, Cremona, O, Di Paolo, G, De Camilli, P, Ryan, TA

Neuron 2007
21613550 Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size

Antonescu, CN, Aguet, F, Danuser, G, Schmid, SL

Mol. Biol. Cell 2011
20826345 Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding

Guan, R, Dai, H, Han, D, Harrison, SC, Kirchhausen, T

Structure 2010
24581490 BAR domain scaffolds in dynamin-mediated membrane fission

Daumke, O, Roux, A, Haucke, V

Cell 2014
10535736 Essential role of phosphoinositide metabolism in synaptic vesicle recycling

Cremona, O, Di Paolo, G, Wenk, MR, L├╝thi, A, Kim, WT, Takei, K, Daniell, L, Nemoto, Y, Shears, SB, Flavell, RA, McCormick, DA, De Camilli, P

Cell 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity of PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane]
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Orthologous Events
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Reviewed
Created