Reactome: A Curated Pathway Database

SYNJ hydrolyze PI(4,5)P2 to PI(4)P

Stable Identifier
R-HSA-8868648
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Inositol-5-phosphatases like SYNJs and OCRL hydrolyze PI(4,5)P2 to PI(4)P. In the context of CME, this promotes the abortive turnover (disassembly) of some CCPs, contributes to the dynamin-mediated scission of the clathrin-coated vesicle neck, and promotes clathrin uncoating following scission (Guan et al, 2010; Cremona et al, 1999; Mani et al, 2007; Chang-Ileto et al, 2011; Antonescu et al, 2011; reviewed in McMahon and Boucrot, 2011; Daumke et al, 2014).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity of PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (0004439)
Orthologous Events