misfolded CFTR [endoplasmic reticulum membrane]

Stable Identifier
R-HSA-8868730
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Cystic fibrosis transmembrane conductance regulator, CFTR_HUMAN
misfolded CFTR [endoplasmic reticulum membrane] icon
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
CFTR, ABCC7
Chain
chain:1-1480
Reference Transcript
Other Identifiers
1080
11722757_at
17050697
205043_PM_at
205043_at
215702_PM_s_at
215702_s_at
3020647
3020648
3020652
3020654
3020658
3020659
3020661
3020662
3020663
3020664
3020666
3020667
3020668
3020670
3020672
3020673
3020674
3020679
3020680
3020682
3020683
3020684
3020685
3020686
3020688
3020689
3020694
3020695
3020696
3020698
3020699
3020701
3020702
3020705
3020706
3020707
3020712
3020719
3020721
3020722
3020723
3020724
3020725
3020726
3020727
36816_s_at
36817_at
3902164
3902300
8135661
A_14_P104877
A_14_P114787
A_14_P129538
A_14_P132049
A_23_P215720
GE62403
GO:0000166
GO:0003824
GO:0005215
GO:0005254
GO:0005260
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005769
GO:0005773
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006629
GO:0006695
GO:0006811
GO:0006821
GO:0006904
GO:0009986
GO:0010008
GO:0015106
GO:0015108
GO:0015701
GO:0016020
GO:0016192
GO:0016324
GO:0016787
GO:0016853
GO:0016887
GO:0017081
GO:0019869
GO:0019899
GO:0022414
GO:0023052
GO:0030154
GO:0030165
GO:0030301
GO:0030660
GO:0030669
GO:0031410
GO:0031901
GO:0032991
GO:0034707
GO:0034976
GO:0035377
GO:0035774
GO:0042626
GO:0043225
GO:0043226
GO:0045921
GO:0048240
GO:0048856
GO:0050891
GO:0051087
GO:0051454
GO:0051649
GO:0055037
GO:0055038
GO:0055085
GO:0060081
GO:0070175
GO:0071320
GO:0097186
GO:0098772
GO:0106138
GO:0140359
GO:0140657
GO:1902161
GO:1902476
GO:1902943
GO:1904322
HMNXSV003020096
Hs.663.1.A1_3p_a_at
ILMN_1705813
M55131_at
PH_hs_0024884
TC07000726.hg
g6995995_3p_at
Participates
Other forms of this molecule
Inferred To
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
707
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
IntEnz
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (656)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O14745 NHRF1      0.932 21
 UniProt:Q15599 NHRF2      0.901 20
 UniProt:P30153 PPP2R1A  2 0.853 16
 UniProt:P27824 CANX  2 0.851 20
 UniProt:Q9HD26 GOPC  3 0.767 10
 UniProt:P60709 ACTB  5 0.731 6
 UniProt:Q9UN37 VPS4A  1 0.725 7
 UniProt:Q9Y678 COPG1  4 0.725 15
 UniProt:P62879 GNB2  4 0.725 12
 UniProt:P10809 HSPD1  6 0.725 16
 UniProt:O00299 CLIC1      0.725 12
 UniProt:Q92734 TFG  7 0.707 7
 UniProt:P02545 LMNA  3 0.706 17
 UniProt:P11021 HSPA5  6 0.706 17
 UniProt:Q13200 PSMD2  5 0.706 17
 UniProt:P06702 S100A9  3 0.706 12
 UniProt:Q14974 KPNB1  5 0.706 16
 UniProt:P31689 DNAJA1  1 0.706 19
 UniProt:P13569 CFTR  17 0.702 12
 UniProt:Q5T2W1 NHRF3      0.702 6
 UniProt:P05787 KRT8  1 0.677 11
 UniProt:P15311 EZR  3 0.671 16
 UniProt:Q14694 USP10  3 0.665 7
 UniProt:P60981 DEST      0.659 10
 UniProt:P31040 SDHA  1 0.659 9
 UniProt:Q9QX74  1 0.658 3
 UniProt:Q9H8Y8 GORASP2  2 0.646 6
 UniProt:P28799 GRN  2 0.643 11
 UniProt:Q15369 ELOC  2 0.643 7
 UniProt:P31151 S100A7  2 0.643 10
 UniProt:P13987 CD59  8 0.643 9
 UniProt:Q15370 ELOB  2 0.643 12
 UniProt:Q96PK6 RBM14  1 0.64 13
 UniProt:Q01518 CAP1  3 0.64 9
 UniProt:Q9Y295 DRG1  2 0.64 9
 UniProt:P09972 ALDOC  5 0.64 8
 UniProt:O95793 STAU1      0.64 8
 UniProt:P62158 CALM      0.64 11
 UniProt:P30101 PDIA3  3 0.64 7
 UniProt:P47756 CAPZB  1 0.64 16
 UniProt:Q99942 RNF5  1 0.636 7
 UniProt:Q9NUU7 DD19A      0.618 9
 UniProt:O14545 TRAD1      0.618 6
 UniProt:Q9UEU0 VTI1B  2 0.618 10
 UniProt:Q9Y608 LRRF2      0.615 10
 UniProt:P14866 HNRNPL  1 0.615 12
 UniProt:Q96CS3 FAF2  3 0.615 9
 UniProt:P62826 RAN  2 0.615 14
 UniProt:P61978 HNRNPK  2 0.615 15
 UniProt:P61619 SEC61A1  2 0.615 9
 UniProt:P00338 LDHA  1 0.615 14
 UniProt:P55060 XPO2      0.615 15
 UniProt:P35579 MYH9  3 0.615 13
 UniProt:P62910 RPL32  1 0.615 11
 UniProt:P13667 PDIA4      0.615 11
 UniProt:Q06830 PRDX1  3 0.615 15
 UniProt:P47897 QARS1  2 0.615 12
 UniProt:P04843 RPN1  1 0.615 14
 UniProt:P17812 CTPS1  1 0.615 14
 UniProt:P12004 PCNA  5 0.615 14
 UniProt:O00410 IPO5  1 0.615 10
 UniProt:P50991 CCT4  1 0.615 12
 UniProt:P38646 HSPA9  6 0.615 15
 UniProt:P56192 MARS1  1 0.615 12
 UniProt:P50402 EMD  4 0.615 7
 UniProt:P23246 SFPQ  3 0.615 14
 UniProt:P55072 VCP  8 0.615 13
 UniProt:Q9UHB6 LIMA1      0.615 15
 UniProt:P04637 TP53  20 0.615 13
 UniProt:Q9P2E9 RRBP1  2 0.615 10
 UniProt:P35232 PHB1  2 0.615 13
 UniProt:P16615 ATP2A2  2 0.615 8
 UniProt:P07910 HNRNPC  3 0.615 10
 UniProt:O00571 DDX3X  3 0.615 14
 UniProt:P13010 XRCC5  4 0.615 13
 UniProt:Q5T4S7 UBR4  5 0.615 10
 UniProt:P22087 FBL  1 0.615 13
 UniProt:P04899 GNAI2  1 0.615 10
 UniProt:P04792 HSPB1  3 0.615 13
 UniProt:P07814 EPRS1  1 0.615 8
 UniProt:P07947 YES1  2 0.615 12
 UniProt:P06733 ENO1  1 0.615 13
 UniProt:P17987 TCP1  1 0.615 13
 UniProt:Q9UKM9 RALY      0.615 10
 UniProt:O60884 DNAJA2  1 0.615 9
 UniProt:P17655 CAPN2  2 0.615 13
 UniProt:P49368 CCT3  1 0.615 10
 UniProt:P05783 KRT18  1 0.615 13
 UniProt:P06753 TPM3  3 0.615 14
 UniProt:P26599 PTBP1  1 0.615 12
 UniProt:Q9UL46 PSME2  2 0.615 11
 UniProt:P31943 HNRNPH1  1 0.615 14
 UniProt:P31944 CASP14  2 0.615 10
 UniProt:P50454 SERPINH1  1 0.615 15
 UniProt:P14174 MIF  3 0.615 11
 UniProt:P57088 TMM33      0.615 15
 UniProt:Q9BR76 COR1B      0.615 7
 UniProt:P53618 COPB1  8 0.615 7
 UniProt:P27348 YWHAQ  1 0.615 15
 UniProt:O14980 XPO1  2 0.615 16
 UniProt:P61160 ACTR2  4 0.615 13
 UniProt:P61163 ACTR1A  1 0.615 6
 UniProt:Q08211 DHX9  3 0.615 14
 UniProt:Q9ULV4 COR1C      0.615 16
 UniProt:P40227 CCT6A  1 0.615 9
 UniProt:Q96N67 DOCK7  1 0.615 13
 UniProt:O95433 AHSA1      0.615 8
 UniProt:P67809 YBX1  5 0.615 13
 UniProt:O95425 SVIL      0.615 12
 UniProt:P78527 PRKDC  4 0.615 14
 UniProt:Q9P035 HACD3  1 0.615 9
 UniProt:Q9BUF5 TUBB6  6 0.615 12
 UniProt:P04075 ALDOA  6 0.615 14
 UniProt:Q8WWI1 LMO7  3 0.615 12
 UniProt:Q9UJW0 DCTN4  1 0.615 8
 UniProt:P04080 CSTB  4 0.615 12
 UniProt:Q12904 AIMP1  1 0.615 12
 UniProt:P52597 HNRNPF  2 0.615 7
 UniProt:P22626 HNRNPA2B1  2 0.615 14
 UniProt:P63244 RACK1  1 0.615 13
 UniProt:P63000 RAC1  6 0.615 12
 UniProt:O43852 CALU  3 0.615 7
 UniProt:O75340 PDCD6      0.615 6
 UniProt:P30041 PRDX6  3 0.615 9
 UniProt:P12956 XRCC6  5 0.615 13
 UniProt:Q8WWM7 ATX2L      0.615 5
 UniProt:A0FGR8 ESYT2  1 0.615 9
 UniProt:P08238 HSP90AB1  6 0.615 16
 UniProt:Q9NYL9 TMOD3  1 0.615 13
 UniProt:Q15393 SF3B3  1 0.615 12
 UniProt:P62191 PSMC1  2 0.615 16
 UniProt:P46779 RPL28  1 0.615 14
 UniProt:Q15233 NONO      0.615 14
 UniProt:P46783 RPS10  2 0.615 14
 UniProt:P37802 TAGLN2  2 0.615 16
 UniProt:P32119 PRDX2  2 0.615 14
 UniProt:P43490 NAMPT  1 0.615 14
 UniProt:Q13155 AIMP2  1 0.615 14
 UniProt:Q14257 RCN2      0.615 11
 UniProt:Q14498 RBM39  1 0.615 14
 UniProt:Q14254 FLOT2  1 0.615 12
 UniProt:Q13045 FLII      0.615 10
 UniProt:P06748 NPM1  11 0.615 15
 UniProt:P22061 PCMT1  1 0.615 14
 UniProt:P63104 YWHAZ  2 0.615 14
 UniProt:P49023 PXN  4 0.615 11
 UniProt:P20700 LMNB1  8 0.615 15
 UniProt:P26641 EEF1G  3 0.615 14
 UniProt:Q08J23 NSUN2  1 0.615 14
 UniProt:P07384 CAPN1  4 0.604 7
 UniProt:Q9BUN8 DERL1  1 0.604 4
 UniProt:O15554 KCNN4  1 0.602 5
 UniProt:P11274 BCR  4 0.595 5
 UniProt:P51572 BCAP31  6 0.583 9
 UniProt:P13646 KRT13  1 0.547 2
 UniProt:Q15323 KRT31  1 0.547 2
 UniProt:Q96S97 MYADM      0.547 3
 UniProt:P08582 MELTF  4 0.547 7
 UniProt:Q14192 FHL2  1 0.547 4
 UniProt:Q9JIL4 NHRF3      0.544 7
 UniProt:P55290 CDH13  1 0.527 7
 UniProt:Q6PID8 KLD10      0.527 5
 UniProt:Q9NQH7 XPP3      0.527 6
 UniProt:Q5EB52 MEST      0.527 9
 UniProt:Q9BU76 MMTAG2  3 0.527 6
 UniProt:P62841 RPS15  2 0.527 9
 UniProt:P04632 CAPNS1  2 0.527 4
 UniProt:O00622 CCN1  2 0.527 10
 UniProt:P62873 GNB1  5 0.527 10
 UniProt:Q9Y3U8 RPL36  1 0.527 7
 UniProt:P05109 S100A8  3 0.527 7
 UniProt:P05121 SERPINE1  3 0.527 10
 UniProt:P0CG39 POTEJ      0.527 9
 UniProt:Q92747 ARPC1A  1 0.527 10
 UniProt:P47914 RPL29  1 0.527 10
 UniProt:P54652 HSPA2  2 0.527 4
 UniProt:P62273 RPS29  2 0.527 9
 UniProt:P56537 IF6      0.527 7
 UniProt:P08107 HSP71      0.527 4
 UniProt:A8MQ03 CRTP1      0.527 3
 UniProt:P09382 LGALS1  2 0.527 10
 UniProt:Q9BQE3 TUBA1C  9 0.527 6
 UniProt:P19474 TRIM21  1 0.527 10
 UniProt:O43852-1 CALU      0.524 2
 UniProt:P07099 EPHX1  1 0.519 5
 UniProt:Q9H7E9 CH033      0.519 5
 UniProt:Q96KC8 DNJC1      0.519 7
 UniProt:P55036 PSMD4  2 0.519 7
 UniProt:O00400 SLC33A1  4 0.519 6
 UniProt:Q9NYY8 FASTKD2  1 0.519 5
 UniProt:Q9UHB9 SRP68  1 0.519 7
 UniProt:P58335 ANTXR2      0.519 2
 UniProt:O75127 PTCD1      0.519 3
 UniProt:O60869 EDF1      0.519 3
 UniProt:Q9UHI6 DDX20  2 0.519 5
 UniProt:Q9HCC0 MCCC2  2 0.519 5
 UniProt:Q96Q45 TM237      0.519 4
 UniProt:Q6UWZ7 ABRAXAS1  1 0.519 3
 UniProt:Q53EZ4 CEP55      0.519 5
 UniProt:Q13616 CUL1  3 0.519 7
 UniProt:Q9P0L0 VAPA  4 0.519 9
 UniProt:Q9BYJ9 YTHD1      0.519 5
 UniProt:Q9NQX7 ITM2C      0.519 2
 UniProt:Q6PI48 DARS2  1 0.519 5
 UniProt:Q9UJY5 GGA1  2 0.519 6
 UniProt:P07203 GPX1  2 0.519 3
 UniProt:Q9P289 STK26  3 0.519 6
 UniProt:P41227 NAA10      0.519 5
 UniProt:Q9NP61 ARFGAP3  1 0.519 8
 UniProt:P08559 PDHA1  1 0.519 5
 UniProt:Q92552 MRPS27  1 0.519 5
 UniProt:P45880 VDAC2  2 0.519 5
 UniProt:P19367 HK1  4 0.519 5
 UniProt:O95292 VAPB  2 0.519 7
 UniProt:P13804 ETFA  1 0.519 5
 UniProt:O43865 AHCYL1  1 0.519 7
 UniProt:Q6P444 MTFR2      0.519 2
 UniProt:Q9P0V3 SH3BP4  1 0.519 4
 UniProt:O15126 SCAMP1  2 0.519 7
 UniProt:P63162 SNRPN  1 0.519 6
 UniProt:Q96HY6 DDRGK1  1 0.519 4
 UniProt:Q13057 COASY  1 0.519 7
 UniProt:Q7L2E3 DHX30      0.519 5
 UniProt:P29353 SHC1  5 0.519 6
 UniProt:O75330 HMMR  2 0.519 7
 UniProt:Q6P6B1 ERIC5      0.508 4
 UniProt:Q14314 FGL2  2 0.508 6
 UniProt:Q8WTP9 XAGE3      0.508 4
 UniProt:Q9Y3X0 CCDC9      0.508 4
 UniProt:O60831 PRAF2      0.508 4
 UniProt:Q8WWA1 TMM40      0.508 4
 UniProt:P0CG30 GSTT2B  1 0.508 4
 UniProt:Q7Z5V6 PPR32      0.508 3
 UniProt:P17026 ZNF22      0.508 2
 UniProt:Q9NSC7 ST6GALNAC1  1 0.508 5
 UniProt:O95154 AKR7A3  1 0.508 4
 UniProt:Q9BXU7 USP26  1 0.508 4
 UniProt:P29762 CRABP1  1 0.508 4
 UniProt:P51790-2 CLCN3      0.499 2
 UniProt:Q9HBW0 LPAR2  1 0.499 3
 UniProt:P11233 RALA  2 0.483 8
 UniProt:Q99959 PKP2  2 0.483 12
 UniProt:Q16891 IMMT  1 0.483 6
 UniProt:Q9NQG5 RPRD1B  1 0.483 7
 UniProt:Q8WUP2 FBLIM1  1 0.483 3
 UniProt:Q99832 CCT7  1 0.483 9
 UniProt:Q9UDY2 TJP2  4 0.483 13
 UniProt:P14868 DARS1  1 0.483 12
 UniProt:P14625 HSP90B1  4 0.483 12
 UniProt:P68371 TUBB4B  8 0.483 12
 UniProt:P24666 PPAC      0.483 9
 UniProt:Q14103 HNRNPD  1 0.483 6
 UniProt:Q16527 CSRP2      0.483 6
 UniProt:P62829 RPL23  1 0.483 12
 UniProt:Q16763 UBE2S  4 0.483 3
 UniProt:Q16643 DBN1  1 0.483 13
 UniProt:P36542 ATP5F1C  1 0.483 12
 UniProt:P11586 MTHFD1  1 0.483 12
 UniProt:Q6PKG0 LARP1  1 0.483 5
 UniProt:P14618 PKM