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CD4 [clathrin-coated endocytic vesicle membrane]
Stable Identifier
R-HSA-8869082
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-coated endocytic vesicle membrane
Icon
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01730 CD4
Gene Names
CD4
Chain
signal peptide:1-25, chain:26-458
Reference Genes
BioGPS Gene:920 CD4
COSMIC (genes):CD4 CD4
CTD Gene:920 CD4
dbSNP Gene:920 CD4
ENSEMBL:ENSG00000010610 CD4
ENSEMBL_homo_sapiens_GENE:ENSG00000010610.10 CD4
HGNC:1678 CD4
KEGG Gene (Homo sapiens):920 CD4
Monarch:920 CD4
NCBI Gene:920 CD4
OMIM:186940 CD4
UCSC:P01730 CD4
Reference Transcript
RefSeq:NM_000616.4 CD4
Other Identifiers
1146_at
11738979_x_at
11738980_a_at
11738981_x_at
11738982_at
11750157_at
16747417
203547_PM_at
203547_at
3402787
3402788
3402790
3402791
3402793
3402798
3402800
3402801
3402802
3402803
3402804
3402807
3402810
3402811
3402812
3402813
3402815
35517_at
48538_at
7953428
920
A_14_P100337
A_24_P295999
GE61155
GO:0001618
GO:0001934
GO:0002250
GO:0002376
GO:0004888
GO:0005198
GO:0005201
GO:0005515
GO:0005768
GO:0005769
GO:0005783
GO:0005788
GO:0005789
GO:0005886
GO:0006351
GO:0006355
GO:0006955
GO:0007155
GO:0007165
GO:0007166
GO:0007167
GO:0007169
GO:0008270
GO:0008289
GO:0009897
GO:0009986
GO:0015026
GO:0016020
GO:0019722
GO:0019899
GO:0019901
GO:0023026
GO:0023052
GO:0030154
GO:0030217
GO:0030225
GO:0030669
GO:0031410
GO:0032507
GO:0032743
GO:0033674
GO:0035397
GO:0035723
GO:0036211
GO:0038023
GO:0042011
GO:0042012
GO:0042101
GO:0042110
GO:0042289
GO:0042802
GO:0042803
GO:0043123
GO:0043226
GO:0043410
GO:0045058
GO:0045121
GO:0045657
GO:0045860
GO:0045893
GO:0046598
GO:0046718
GO:0048856
GO:0050731
GO:0050829
GO:0050850
GO:0050863
GO:0050870
GO:0051924
GO:0060089
GO:0070374
GO:0097011
GO:0098542
GO:1990782
HMNXSV003005320
HMNXSV003009618
Hs.17483.0.S2_3p_at
ILMN_1727284
PH_hs_0001579
TC12000092.hg
TC12002205.hg
Participates
as a member of
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
CD4 [early endosome]
CD4 [endoplasmic reticulum membrane]
CD4 [plasma membrane]
Inferred To
Cd4 [clathrin-coated endocytic vesicle membrane]
(Mus musculus)
Cd4 [clathrin-coated endocytic vesicle membrane]
(Rattus norvegicus)
CD4 [clathrin-coated endocytic vesicle membrane]
(Bos taurus)
CD4 [clathrin-coated endocytic vesicle membrane]
(Canis familiaris)
CD4 [clathrin-coated endocytic vesicle membrane]
(Gallus gallus)
CD4 [clathrin-coated endocytic vesicle membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000607.1
Guide to Pharmacology - Targets
2995
OpenTargets
ENSG00000010610
GeneCards
P01730
ZINC - Substances
CD4_HUMAN
HPA
ENSG00000010610-CD4
ZINC target
P01730
Ensembl
ENSG00000010610
,
ENST00000011653
,
ENSP00000011653
PRO
P01730
Pharos - Targets
P01730
ZINC - Predictions - Purchasable
CD4_HUMAN
PDB
1G9M
,
2NY2
,
6OPQ
,
3CD4
,
2NY3
,
6L1Y
,
1WIP
,
5A7X
,
3S5L
,
3J70
,
4P9H
,
6X5B
,
2JKT
,
1JL4
,
4JM2
,
1G9N
,
1CDU
,
6URI
,
6OPP
,
1Q68
,
5U1F
,
6MEO
,
3LQA
,
2NXY
,
2NY0
,
6OPO
,
2KLU
,
6OPN
,
5A8H
,
3B71
,
1CDI
,
6CM3
,
8D5C
,
7T0O
,
1RZK
,
1RZJ
,
8FYJ
,
3T0E
,
3JWO
,
2NY5
,
3JCB
,
2NY4
,
8FYI
,
6X5C
,
4H8W
,
3JCC
,
5CAY
,
4R4H
,
7TXD
,
2JKR
,
6QH6
,
2NXZ
,
6MET
,
2NY1
,
3O2D
,
5THR
,
6EDU
,
7T0R
,
4R2G
,
4Q6I
,
1WIO
,
5VN3
,
2NY6
,
1GC1
,
1CDJ
,
2B4C
,
4RQS
,
6U0N
,
1WIQ
,
3JWD
,
1CDY
,
2QAD
,
1CDH
,
6QH7
,
3S4S
,
1WBR
,
6U0L
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.702
3
UniProt:P51681 CCR5
1
CCR5 [plasma membrane]
(R-HSA-171279)
0.667
3
UniProt:P04578-PRO_0000038427 ENV
0.618
3
UniProt:Q2N0S6 Q2N0S6
0.618
3
UniProt:Q1PHM6 Q1PHM6
0.558
2
UniProt:P01730 CD4
4
CD4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869082)
CD4 [early endosome]
(R-HSA-182147)
CD4 [endoplasmic reticulum membrane]
(R-HSA-180575)
CD4 [plasma membrane]
(R-HSA-167542)
0.558
2
UniProt:P03407 NEF
0.558
2
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.558
2
UniProt:Q9Y371 SHLB1
0.556
3
UniProt:P13473-2 P134732
0.556
3
UniProt:A6NKD9 CC85C
0.527
2
UniProt:Q9NPF0 CD320
2
CD320 [plasma membrane]
(R-HSA-2980909)
CD320 E88del [plasma membrane]
(R-HSA-3325560)
0.527
2
UniProt:Q9H2C2 ARV1
1
ARV1 [endoplasmic reticulum membrane]
(R-HSA-5216144)
0.527
2
UniProt:Q15836 VAMP3
6
VAMP3 [recycling endosome membrane]
(R-HSA-2029063)
VAMP3 [phagocytic vesicle membrane]
(R-HSA-2029013)
VAMP3 [plasma membrane]
(R-HSA-8867599)
VAMP3 [trans-Golgi network membrane]
(R-HSA-6814624)
VAMP3 [transport vesicle]
(R-HSA-6814625)
VAMP3 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869130)
0.527
2
UniProt:Q96ER3 SAAL1
0.527
2
UniProt:Q9Y487 ATP6V0A2
2
ATP6V0A2 [phagocytic vesicle membrane]
(R-HSA-1222546)
ATP6V0A2 [endosome membrane]
(R-HSA-912595)
0.527
2
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.524
3
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