Reactome | TFRC(1-760) [clathrin-coated endocytic vesicle membrane]

TFRC(1-760) [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869124

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

TFRC, Transferrin receptor protein 1

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02786 TFRC

Gene Names

TFRC

Chain

chain:1-760, chain:101-760

Reference Genes

BioGPS Gene:7037 TFRC

COSMIC (genes):TFRC TFRC

CTD Gene:7037 TFRC

dbSNP Gene:7037 TFRC

ENSEMBL:ENSG00000072274 TFRC

HGNC:11763 TFRC

KEGG Gene (Homo sapiens):7037 TFRC

Monarch:7037 TFRC

NCBI Gene:7037 TFRC

OMIM:190010 TFRC

UCSC:P02786 TFRC

Reference Transcript

Other Identifiers

0002260465

11715477_at

11715478_a_at

11756156_s_at

153

16963241

1CX8

1DE4

1SUV

207332_s_at

208691_at

237215_s_at

2712637

2712638

2712639

2712640

2712641

2712642

2712643

2712645

2712650

2712652

2712654

2712658

2712660

2712664

2712665

2712668

2712669

2712671

2712675

2712676

2712677

2712678

2712679

2712681

2712684

2712685

28598

2NSU

37324_at

3KAS

3S9L

3S9M

3S9N

6D03

6D04

6D05

7037

8093053

A_23_P212617

AAA61153

AAF04564

AAH01188

AB209254

ABF47088

AF187320

AFFX-HUMTFRR/M11507_3_at

AFFX-HUMTFRR/M11507_5_at

AFFX-HUMTFRR/M11507_M_at

BAD92491

BC001188

CAA25527

CAB000153

CCDS3312

CH471191

DQ496099

EAW53670

EAW53673

ENSG00000072274

ENSP00000353224

ENSP00000376197

ENST00000360110

ENST00000360110.8

ENST00000392396

ENST00000392396.7

EntrezGene:7037

EntrezGene:TFRC

F8WBE5

G3V0E5

g4507456_3p_a_at

GE81249

GO:0001618

GO:0002376

GO:0003674

GO:0003723

GO:0003725

GO:0004998

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005768

GO:0005769

GO:0005886

GO:0005887

GO:0005905

GO:0006259

GO:0006810

GO:0006826

GO:0006879

GO:0006897

GO:0006898

GO:0007155

GO:0008150

GO:0008283

GO:0009897

GO:0009986

GO:0010008

GO:0016020

GO:0016021

GO:0016032

GO:0016192

GO:0016323

GO:0022857

GO:0030154

GO:0030316

GO:0030665

GO:0030890

GO:0031410

GO:0031623

GO:0032991

GO:0033570

GO:0033572

GO:0034641

GO:0035690

GO:0042102

GO:0042470

GO:0042592

GO:0042802

GO:0042803

GO:0043226

GO:0044403

GO:0045780

GO:0045830

GO:0046718

GO:0048471

GO:0048856

GO:0055037

GO:0061024

GO:0070062

GO:0072562

GO:1903561

GO:1990712

GO:1990830

H7C3V5

HGNC:11763

HPA028598

ILMN_1853411

IPR003137

IPR007365

IPR007484

IPR029513

IPR036757

IPR037324

IPR039373

M11507

MIM:190010

MIM:616740

NM_001128148

NM_003234

NP_001121620

NP_003225

PF02225

PF04253

PF04389

PH_hs_0022877

TC03002155.hg

TFRC

TFRC-201

TFRC-202

UPI0000049ADE

X01060

X01060_at

XM_024453731

XM_024453732

XP_024309499

XP_024309500

XR_002959575

XR_002959576

XR_002959577

XR_002959578

Participant Of

hasComponent

TFRC dimer [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

TFRC(1-760) [endosome membrane]

TFRC(1-760) [plasma membrane]

TFRC(1-760) [cytoplasmic vesicle membrane]

TFRC(1-760) [Golgi membrane]

Inferred To

TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Danio rerio)

TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Mus musculus)

TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001300894.1, NP_003225.2, NP_001121620.1, NP_001300895.1

OpenTargets

ENSG00000072274

GeneCards

P02786

PRO

P02786

Orphanet

24978

HMDB Protein

HMDBP02577

PDB

2NSU, 3S9N, 6D03, 1CX8, 3KAS, 6H5I, 3S9M, 1SUV, 6GSR, 6D04, 3S9L, 1DE4, 6D05

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02787 TF	6	TF [secretory granule lumen] (R-HSA-350704) apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140) apoTF [extracellular region] (R-HSA-350754) apoTF [endosome membrane] (R-HSA-917974) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) TF [endoplasmic reticulum lumen] (R-HSA-8956763)	0.935	11
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.668	6
UniProt:Q30201 HFE	1	HFE [plasma membrane] (R-HSA-5691126)	0.621	3
UniProt:P21926 CD9	4	CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [plasma membrane] (R-HSA-51717) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.597	3
UniProt:P61769 B2M	11	B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [early endosome membrane] (R-HSA-182298) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [plasma membrane] (R-HSA-167743)	0.564	3
UniProt:P02768 ALB	5	ALB [platelet alpha granule lumen] (R-HSA-49865) ALB(19-609) [extracellular region] (R-HSA-114609) ALB [extracellular region] (R-HSA-194115) p-ALB [endoplasmic reticulum lumen] (R-HSA-8956930) ALB [endoplasmic reticulum lumen] (R-HSA-8956690)	0.558	2
UniProt:P04626 ERBB2	12	p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
ganglioside GM1 [ChEBI:61048]	2	GM1 [external side of plasma membrane] (R-ALL-8850300) GM1 [lysosomal membrane] (R-ALL-1605677)	0.524	2
UniProt:Q96BA8 CREB3L1	7	CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.488	2
UniProt:Q3SXY8 ARL13B	2	ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129)	0.488	2
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.488	2
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]	6	PI(3,4,5)P3 [endocytic vesicle membrane] (R-ALL-917725) PIP3 [plasma membrane] (R-ALL-38117) PI(3,4,5)P3 [endosome membrane] (R-ALL-917716) PI(3,4,5)P3 [early endosome membrane] (R-ALL-8849955) PI(3,4,5)P3 [cytoplasmic vesicle membrane] (R-ALL-8874468) PI(3,4,5)P3 [plasma membrane] (R-ALL-179838)	0.462	2