Reactome | ATXN7 [nucleoplasm]

ATXN7 [nucleoplasm]

Stable Identifier

R-HSA-8869458

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

*Ataxin-7

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)
        
        USP3, SAGA complex [nucleoplasm] (Homo sapiens)
        
        SAGA [nucleoplasm] (Homo sapiens)
        
        ATXN7 [nucleoplasm] (Homo sapiens)
        
        USP3,SAGA:Histone H2A,Histone H2B [nucleoplasm] (Homo sapiens)
        
        USP3, SAGA complex [nucleoplasm] (Homo sapiens)
        
        SAGA [nucleoplasm] (Homo sapiens)
        
        ATXN7 [nucleoplasm] (Homo sapiens)
        
        USP3,SAGA:Ub-histone H2A, Ub-histone H2B [nucleoplasm] (Homo sapiens)
        
        USP3, SAGA complex [nucleoplasm] (Homo sapiens)
        
        SAGA [nucleoplasm] (Homo sapiens)
        
        ATXN7 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15265 ATXN7

Gene Names

ATXN7, SCA7

Chain

chain:1-892

Reference Genes

BioGPS Gene:6314 ATXN7

COSMIC (genes):ATXN7 ATXN7

CTD Gene:6314 ATXN7

dbSNP Gene:6314 ATXN7

ENSEMBL:ENSG00000163635 ATXN7

ENSEMBL:ENSG00000285258 ATXN7

HGNC:10560 ATXN7

KEGG Gene (Homo sapiens):6314 ATXN7

Monarch:6314 ATXN7

NCBI Gene:6314 ATXN7

OMIM:607640 ATXN7

UCSC:O15265 ATXN7

Reference Transcript

Other Identifiers

0004120605

11731022_a_at

11731023_a_at

11731024_s_at

11744609_a_at

11748420_a_at

16942392

204516_at

209964_s_at

232527_at

243259_at

2627391

2627392

2627397

2627400

2627401

2627402

2627403

2627413

2627420

2627422

2627423

2627424

2627427

2627428

2627430

2627433

2627434

2627435

2627436

2627437

2627439

2627442

2627443

2627444

2627445

2627446

2627447

2627448

2627449

2627450

2627453

2627455

2627456

2627457

2627464

2627466

37167_at

43242_at

51174_at

6314

8080878

91380_at

A_14_P102272

A_14_P103923

A_23_P257155

A_24_P25074

A_33_P3320782

GE55130

GO:0000226

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005856

GO:0006464

GO:0006997

GO:0007010

GO:0007026

GO:0007601

GO:0008150

GO:0015630

GO:0016363

GO:0016578

GO:0016579

GO:0043226

GO:0050877

GO:0051276

Hs.108447.0.S2_3p_at

Hs.151845.0.A1_3p_at

Hs.282421.1.A1_3p_at

ILMN_1688602

ILMN_1913537

PH_hs_0006006

TC03000394.hg

TC03002368.hg

g3192953_3p_a_at

Participant Of

hasComponent

SAGA [nucleoplasm]

Other forms of this molecule

ATXN7 [cytosol]

Inferred To

ATXN7 [nucleoplasm] (Bos taurus)

ATXN7 [nucleoplasm] (Canis familiaris)

ATXN7 [nucleoplasm] (Sus scrofa)

Ghost homologue of ATXN7 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of ATXN7 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of ATXN7 [nucleoplasm] (Schizosaccharomyces pombe)

atxn7 [nucleoplasm] (Danio rerio)

atxn7 [nucleoplasm] (Xenopus tropicalis)

Atxn7 [nucleoplasm] (Mus musculus)

Atxn7 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_000324.1, NP_001170858.1, NP_001121621.2

OpenTargets

ENSG00000285258

GeneCards

O15265

HPA

ENSG00000285258-ATXN7, ENSG00000163635-ATXN7

Ensembl

ENSP00000428067, ENSP00000428277, ENSP00000420234, ENSP00000439585, ENST00000295900, ENST00000484332, ENSG00000163635, ENSP00000295900, ENST00000487717, ENST00000538065, ENST00000522345

PRO

O15265

Orphanet

15340

PDB

2KKR

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4A5 TRRAP	1	TRRAP [nucleoplasm] (R-HSA-3322951)	0.558	6
UniProt:Q92830 KAT2A	1	KAT2A [nucleoplasm] (R-HSA-3006516)	0.558	5
UniProt:Q9Y3T9 NOC2L	1	NOC2L [nucleoplasm] (R-HSA-3222129)	0.508	2
UniProt:O00468 AGRN	26	AGRN(30-2045) [lysosomal lumen] (R-HSA-2090057) AGRN(30-2045) [plasma membrane] (R-HSA-2090084) HS(6)-AGRN [lysosomal lumen] (R-HSA-2090081) HS(5)-AGRN [plasma membrane] (R-HSA-2076642) HS(3)-AGRN [plasma membrane] (R-HSA-2076663) HS(1)-AGRN [plasma membrane] (R-HSA-2076634) HS(2)-AGRN [plasma membrane] (R-HSA-2076686) HS(6)-AGRN [plasma membrane] (R-HSA-2076678) HS(4)-AGRN [plasma membrane] (R-HSA-2076654) HS(6)-AGRN [Golgi lumen] (R-HSA-2076568) HS(5)-AGRN [Golgi lumen] (R-HSA-2076606) Heparan-AGRN [Golgi lumen] (R-HSA-2076530) Heparan(1)-AGRN [Golgi lumen] (R-HSA-2076317) Heparan(2)-AGRN [Golgi lumen] (R-HSA-2076301) Heparan(3)-AGRN [Golgi lumen] (R-HSA-2076569) AGRN(30-2045) [extracellular region] (R-HSA-375056) XylS-AGRN(30-2045) [Golgi lumen] (R-HSA-2064220) Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064130) AGRN(30-2045) [Golgi lumen] (R-HSA-2054104) Gal-Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064040) GlcA-Gal-Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064200) HS(3)-AGRN [Golgi lumen] (R-HSA-2076493) HS(4)-AGRN [Golgi lumen] (R-HSA-2076337) HS(2)-AGRN [Golgi lumen] (R-HSA-2076521) HS(1)-AGRN [Golgi lumen] (R-HSA-2076350) Heparan(4)-AGRN [Golgi lumen] (R-HSA-2076300)	0.508	2
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.508	2
UniProt:Q8N2S1 LTBP4	1	LTBP4 [extracellular region] (R-HSA-2161309)	0.508	2
UniProt:P02283	15	His2B [nucleoplasm] (R-DME-6782554) His2B [nucleoplasm] (R-DME-6782561) His2B [nucleoplasm] (R-DME-4549263) His2B [nucleoplasm] (R-DME-4549272) His2B [nucleoplasm] (R-DME-4568624) His2B [nucleoplasm] (R-DME-4568615) His2B [nucleoplasm] (R-DME-4568631) His2B [nucleoplasm] (R-DME-4568647) His2B [nucleoplasm] (R-DME-4568660) His2B [nucleoplasm] (R-DME-4568632) His2B [nucleoplasm] (R-DME-4568629) His2B [nucleoplasm] (R-DME-4568639) His2B [nucleoplasm] (R-DME-4568637) His2B [nucleoplasm] (R-DME-181916) His2B [nucleoplasm] (R-DME-181898)	0.499	2

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