TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation

Stable Identifier
R-HSA-8869496
Type
Pathway
Species
Homo sapiens
Compartment
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Summation

During retinoic acid-induced cell differentiation, TFAP2A, in complex with NPM1 (nucleophosmin), represses transcription of HSPD1 (Hsp60), NOP2 (p120) and MYBL2 (b-Myb). The repression of gene expression probably involves the recruitment of histone deacetylases HDAC1 and HDCA2 to target promoters by NPM1. The complex of TFAP2A and NPM1 can also be detected at the NPM1 promoter, which is in agreement with decreased NPM1 expression after retinoic acid treatment. The level of TFAP2A increases in response to the retinoic acid treatment (Liu et al. 2007). NOP2 and MYBL2 are both proliferation markers (Valdez et al. 1992, Saville and Watson 1998).

Literature References
PubMed ID Title Journal Year
1394192 A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation

Valdez, BC, Perlaky, L, Saijo, Y, Henning, D, Zhu, C, Busch, RK, Zhang, WW, Busch, H

Cancer Res. 1992
9840932 The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties

Saville, MK, Watson, RJ

Oncogene 1998
17318229 Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation

Liu, H, Tan, BC, Tseng, KH, Chuang, CP, Yeh, CW, Chen, KD, Lee, SC, Yung, BY

EMBO Rep. 2007
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