TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6

Stable Identifier
R-HSA-8869506
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TNFAIP3 can remove K63-linked ubiquitin from TRAF6, which terminates signalling by Toll-like receptors (Boone et al. 2004). TNFAIP3 is essential for the termination of NFkappaB activation in response to multiple stimuli such as IL-1beta, TNF, IL-6, CD40 and lipopolysaccharide (LPS). Removal of K63-linked ubiquitin is not necessarily followed by K48-ubiquitination that would lead to degradation (Vereecke et al. 2009).

Literature References
PubMed ID Title Journal Year
15334086 The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

Boone, DL, Turer, EE, Lee, EG, Ahmad, RC, Wheeler, MT, Tsui, C, Hurley, P, Chien, M, Chai, S, Hitotsumatsu, O, McNally, E, Pickart, C, Ma, A

Nat. Immunol. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Lys63-specific deubiquitinase activity of OTUD7B,TNFAIP3,ZRANB1:K63polyUb-TRAF6 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed