HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer

Stable Identifier
R-HSA-8869558
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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Summation

In the course of retinoic acid-induced cell differentiation, formation of the complex between NPM1 (nucleophosmin) and TFAP2A (AP-2 alpha) homodimer, bound to the AP-2 alpha response element in the promoter of the HSPD1 (Hsp60) gene, represses transcription of the mitochondrial matrix chaperonin HSPD1. Transcriptional repression probably involves NPM1-mediated recruitment of histone deacetylases HDAC1 and HDAC2 to the HSPD1 gene promoter (Liu et al. 2007).

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