Reactome: A Curated Pathway Database

The NOP2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer

Stable Identifier
R-HSA-8869560
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In the course of retinoic acid-induced cell differentiation, formation of the complex between NPM1 (nucleophosmin) and TFAP2A (AP-2 alpha) homodimer, bound to the AP-2 alpha response element in the promoter of the NOP2 (p120) gene, represses transcription of the nucleolar protein NOP2. Transcriptional repression probably involves NPM1-mediated recruitment of histone deacetylases HDAC1 and HDAC2 to the NOP2 gene promoter (Liu et al. 2007). NOP2 is a proliferation marker (Valdez et al. 1992).

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