DEK is recruited to the APOE gene promoter via its interaction with the TFAP2A (AP-2 alpha) homodimer. In the presence of DEK, TFAP2A associates with the APOE promoter more tightly (Campillos et al. 2003). Binding of TFAP2A to the APOE gene promoter may be stimulated by PKA-mediated phosphorylation of TFAP2A (Garcia et al. 1999).