TFAP2A in complex with DEK binds the APOE gene promoter

Stable Identifier
R-HSA-8869575
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

DEK is recruited to the APOE gene promoter via its interaction with the TFAP2A (AP-2 alpha) homodimer. In the presence of DEK, TFAP2A associates with the APOE promoter more tightly (Campillos et al. 2003). Binding of TFAP2A to the APOE gene promoter may be stimulated by PKA-mediated phosphorylation of TFAP2A (Garcia et al. 1999).

Literature References
PubMed ID Title Journal Year
12595566 Transcriptional activation by AP-2alpha is modulated by the oncogene DEK Nucleic Acids Res. 2003
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