NMRK1 phosphorylates NAR to yield NAMN

Stable Identifier
R-HSA-8869606
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
NAR + ATP(4-) => NAMN + ADP(3-) + H+
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NMRK1 (nicotinamide riboside kinase 1) catalyzes the reaction of NAR (N-ribosylnicotinate) and ATP to yield NAMN (beta-nicotinate D-ribonucleotide), ADP, and H+ (Tempel et al. 2007). The reaction is annotated with ATP(4-), the major ionized form of ATP at pH 7.2 (Stockbridge & Wolfenden 2009), as the phosphate donor. NMRK1 is a cytosolic enzyme (Nikiforov et al. 2011).

Literature References
PubMed ID Title Journal Year
17914902 Nicotinamide riboside kinase structures reveal new pathways to NAD+

Tempel, W, Rabeh, WM, Bogan, KL, Belenky, P, Wojcik, M, Seidle, HF, Nedyalkova, L, Yang, T, Sauve, AA, Park, HW, Brenner, C

PLoS Biol. 2007
21504897 Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation

Nikiforov, A, Dölle, C, Niere, M, Ziegler, M

J. Biol. Chem. 2011
19531469 The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis

Stockbridge, RB, Wolfenden, R

J. Biol. Chem. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ribosylnicotinate kinase activity of NMRK1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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