NMRK2 phosphorylates NR to yield NMN

Stable Identifier
R-HSA-8869627
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
NR + ATP(4-) => NMN + ADP(3-) + H+
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NMRK2 (nicotinamide riboside kinase 2) catalyzes the reaction of NR (N-ribosylnicotinamide) and ATP to yield NMN (beta-nicotinamide D-ribonucleotide), ADP, and H+ (Bieganowsky & Brenner 2004; Tempel et al. 2007). The reaction is annotated with ATP(4-), the major ionized form of ATP at pH 7.2 (Stockbridge & Wolfenden 2009), as the phosphate donor. NMRK2 is a cytosolic enzyme (Nikiforov et al. 2011), localized predominantly in myocytes (Li et al. 1999).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ribosylnicotinamide kinase activity of NMRK2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created