oxLDL:CD36 binds TLR4:TLR6

Stable Identifier
R-HSA-8869667
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Oxidized low-density lipoprotein (oxLDL) and amyloid-beta sequestered by the scavenger receptor CD36 trigger sterile inflammatory signaling through a CD36:TLR4:TLR6 heteromerization (Stewart CR et al., 2010). The heterotrimeric CD36:TLR4:TLR6 signaling complex, acting via NFkappaB and reactive oxygen species, primes the NLRP3 inflammasome in response to oxLDL (Sheedy FJ et al., 2013).

Participants
Participant Of
Orthologous Events