Oxidized low-density lipoprotein (oxLDL) and amyloid-beta sequestered by the scavenger receptor CD36 trigger sterile inflammatory signaling through a CD36:TLR4:TLR6 heteromerization (Stewart CR et al., 2010). The heterotrimeric CD36:TLR4:TLR6 signaling complex, acting via NFkappaB and reactive oxygen species, primes the NLRP3 inflammasome in response to oxLDL (Sheedy FJ et al., 2013).
Stewart, CR, Stuart, LM, Wilkinson, K, van Gils, JM, Deng, J, Halle, A, Rayner, KJ, Boyer, L, Zhong, R, Frazier, WA, Lacy-Hulbert, A, El Khoury, J, Golenbock, DT, Moore, KJ
Endemann, G, Stanton, LW, Madden, KS, Bryant, CM, White, RT, Protter, AA
© 2021 Reactome
