Reactome | oxLDL:CD36 binds TLR4:TLR6

oxLDL:CD36 binds TLR4:TLR6

Stable Identifier

R-HSA-8869667

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Oxidized low-density lipoprotein (oxLDL) and amyloid-beta sequestered by the scavenger receptor CD36 trigger sterile inflammatory signaling through a CD36:TLR4:TLR6 heteromerization (Stewart CR et al., 2010). The heterotrimeric CD36:TLR4:TLR6 signaling complex, acting via NFkappaB and reactive oxygen species, primes the NLRP3 inflammasome in response to oxLDL (Sheedy FJ et al., 2013).

Literature References

PubMed ID	Title	Journal	Year
7685021	CD36 is a receptor for oxidized low density lipoprotein Endemann, G, Stanton, LW, Madden, KS, Bryant, CM, White, RT, Protter, AA	J Biol Chem	1993
20037584	CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer Stewart, CR, Stuart, LM, Wilkinson, K, van Gils, JM, Deng, J, Halle, A, Rayner, KJ, Boyer, L, Zhong, R, Frazier, WA, Lacy-Hulbert, A, El Khoury, J, Golenbock, DT, Moore, KJ	Nat. Immunol.	2010