BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose

Stable Identifier
R-HSA-8870346
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
NAD(+) + H2O => NAM + ADP-ribose + H+
Locations in the PathwayBrowser
General
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BST1 dimer associated with the plasma membrane catalyzes the hydrolysis of extracellular NAD+ to yield NAM and ADP-ribose (Yamamoto-Katayama et al. 2002).

Literature References
PubMed ID Title Journal Year
11866528 Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities

Yamamoto-Katayama, S, Ariyoshi, M, Ishihara, K, Hirano, T, Jingami, H, Morikawa, K

J. Mol. Biol. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD+ nucleosidase activity of BST1 dimer [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created