RABGGTA and RABGGTB bind

Stable Identifier
R-HSA-8870461
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RABGGTA and RABGGTB are the two catalytic subunits of a trimeric RAB geranylgeranyl transferase complex (GGTase); the third subunit is the RAB binding subunit CHM or CHML (reviewed in Leung et al, 2006; Gutkowska and Swiezewska, 2012). RABGGTB also interacts in a mutually exclusive way with PTP4A2, preventing formation of a functional gernanylgeranyl transferase complex (Si et al, 2001; Baron and Seabra, 2008). Newly synthesized RAB proteins are singly or more commonly doubly geranylgeranylated near their C-termini by the GGTase. Geranylgeranylation promotes association of active RAB proteins with membranes. Membrane association is additionally modulated by the nucleotide state of the GTPase through regulatory proteins such as guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs) and GDP Dissocation Inhibitors (GDIs), among others (reviewed in Stenmark et al, 2009; Wandinger-Ness and Zerial, 2014). An exception to this is RAB13, which has recently been shown to be membrane-associated even in the inactive state and to traffic on vesicles independently of geranylgeranylation (Ioannou et al, 2016).

Literature References
PubMed ID Title Journal Year
26969162 Rab13 Traffics on Vesicles Independent of Prenylation

Ioannou, MS, Girard, M, McPherson, PS

J. Biol. Chem. 2016
19603039 Rab GTPases as coordinators of vesicle traffic

Stenmark, H

Nat. Rev. Mol. Cell Biol. 2009
22694141 Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein

Gutkowska, M, Swiezewska, E

Mol. Membr. Biol. 2012
16401880 Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases

Leung, KF, Baron, R, Seabra, MC

J. Lipid Res. 2006
18532927 Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate

Baron, RA, Seabra, MC

Biochem. J. 2008
11447212 Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II

Si, X, Zeng, Q, Ng, CH, Hong, W, Pallen, CJ

J. Biol. Chem. 2001
25341920 Rab proteins and the compartmentalization of the endosomal system

Wandinger-Ness, A, Zerial, M

Cold Spring Harb Perspect Biol 2014
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