Reactome | RABGGTA and RABGGTB bind

RABGGTA and RABGGTB bind

Stable Identifier

R-HSA-8870461

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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RABGGTA and RABGGTB are the two catalytic subunits of a trimeric RAB geranylgeranyl transferase complex (GGTase); the third subunit is the RAB binding subunit CHM or CHML (reviewed in Leung et al, 2006; Gutkowska and Swiezewska, 2012). RABGGTB also interacts in a mutually exclusive way with PTP4A2, preventing formation of a functional gernanylgeranyl transferase complex (Si et al, 2001; Baron and Seabra, 2008). Newly synthesized RAB proteins are singly or more commonly doubly geranylgeranylated near their C-termini by the GGTase. Geranylgeranylation promotes association of active RAB proteins with membranes. Membrane association is additionally modulated by the nucleotide state of the GTPase through regulatory proteins such as guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs) and GDP Dissocation Inhibitors (GDIs), among others (reviewed in Stenmark et al, 2009; Wandinger-Ness and Zerial, 2014). An exception to this is RAB13, which has recently been shown to be membrane-associated even in the inactive state and to traffic on vesicles independently of geranylgeranylation (Ioannou et al, 2016).

Literature References

PubMed ID	Title	Journal	Year
19603039	Rab GTPases as coordinators of vesicle traffic Stenmark, H	Nat. Rev. Mol. Cell Biol.	2009
26969162	Rab13 Traffics on Vesicles Independent of Prenylation Ioannou, MS, McPherson, PS, Girard, M	J. Biol. Chem.	2016
22694141	Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein Swiezewska, E, Gutkowska, M	Mol. Membr. Biol.	2012
16401880	Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases Seabra, MC, Leung, KF, Baron, R	J. Lipid Res.	2006
18532927	Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate Seabra, MC, Baron, RA	Biochem. J.	2008
11447212	Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II Hong, W, Si, X, Ng, CH, Pallen, CJ, Zeng, Q	J. Biol. Chem.	2001
25341920	Rab proteins and the compartmentalization of the endosomal system Wandinger-Ness, A, Zerial, M	Cold Spring Harb Perspect Biol	2014