Reactome: A Curated Pathway Database

CDK5:p25 phosphorylates FOXO3

Stable Identifier
R-HSA-8870558
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CDK5, aberrantly activated by binding to p25, phosphorylates transcription factor FOXO3 on serine residues S43, S173, S294 and S325 (Shi et al. 2016).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of CDK5:p25 [cytosol] CDK5:p25 [cytosol] protein serine/threonine kinase activity (0004674)
Inferred From
Disease
Diseases
Name Identifier Synonyms
Alzheimer's disease 10652 AD, Alzheimers dementia, Alzheimer disease