BCL2L11 (BIM) gene expression

Locations in the PathwayBrowser

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Disease (Homo sapiens)

• • Neurodegenerative Diseases (Homo sapiens)
    • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
      • BCL2L11 (BIM) gene expression (Homo sapiens)

Summation

Transcription of the pro-apoptotic BCL2L11 (BIM) gene is stimulated by FOXO3 downstream of CDK5-mediated FOXO3 phosphorylation (Shi et al. 2016).

Literature References

PubMed ID	Title	Journal	Year

26962010

Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models

J. Cell. Sci.

2016

Participants

input

• BCL2L11 gene [nucleoplasm] (Homo sapiens)

output

• BCL2L11 [mitochondrial outer membrane] (Homo sapiens)

Participant Of

hasEvent

• Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

This entity is regulated by:

Positive Regulation

• FOXO3 positively regulates BCL2L11 (BIM) gene expression

Disease

Diseases

Name	Identifier	Synonyms

Alzheimer's disease

10652

AD, Alzheimers dementia, Alzheimer disease