Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CLTC [endolysosome membrane]
Stable Identifier
R-HSA-8870827
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endolysosome membrane
Synonyms
Clathrin heavy chain 1, CLH1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLTC [endolysosome membrane] (Homo sapiens)
Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLTC [endolysosome membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLTC [endolysosome membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
LDL clearance (Homo sapiens)
Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLTC [endolysosome membrane] (Homo sapiens)
PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLTC [endolysosome membrane] (Homo sapiens)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Homo sapiens)
PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLTC [endolysosome membrane] (Homo sapiens)
VLDLR internalisation and degradation (Homo sapiens)
VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Homo sapiens)
VLDL:PCSK9:Clathrin:AP2 [lysosomal membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLTC [endolysosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00610 CLTC
Gene Names
CLTC, CLH17, CLTCL2, KIAA0034
Chain
initiator methionine:, chain:2-1675
Reference Genes
COSMIC (genes):CLTC CLTC
dbSNP Gene:1213 CLTC
ENSEMBL:ENSG00000141367 CLTC
Participates
as a component of
Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
CLTC [trans-Golgi network membrane]
CLTC [cytosol]
CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol]
CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol]
CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol]
CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol]
CLTC [clathrin-coated endocytic vesicle membrane]
CLTC [lysosomal membrane]
CLTC [plasma membrane]
Inferred To
CLTC [endolysosome membrane]
(Bos taurus)
CLTC [endolysosome membrane]
(Canis familiaris)
CLTC [endolysosome membrane]
(Gallus gallus)
CLTC [endolysosome membrane]
(Sus scrofa)
Chc [endolysosome membrane]
(Drosophila melanogaster)
Ghost homologue of CLTC [endolysosome membrane]
(Danio rerio)
Ghost homologue of CLTC [endolysosome membrane]
(Xenopus tropicalis)
chc-1 [endolysosome membrane]
(Caenorhabditis elegans)
chc1 [endolysosome membrane]
(Schizosaccharomyces pombe)
CHC1 [endolysosome membrane]
(Saccharomyces cerevisiae)
Cltc [endolysosome membrane]
(Mus musculus)
Cltc [endolysosome membrane]
(Rattus norvegicus)
chcA [endolysosome membrane]
(Dictyostelium discoideum)
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.676
6
UniProt:Q15398 DLGAP5
1
DLGAP5 [cytosol]
(R-HSA-264452)
0.645
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
21
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.597
3
UniProt:Q14164 IKBKE
5
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
K63polyUb-K30,K401-IKBKE [cytosol]
(R-HSA-9730436)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
0.589
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.569
11
UniProt:Q9NYZ3 GTSE1
4
GTSE1 [cytosol]
(R-HSA-8852264)
p-S435-GTSE1 [cytosol]
(R-HSA-8852316)
p-S435-GTSE1 [nucleoplasm]
(R-HSA-8852332)
p-T513,T526-GTSE1 [cytosol]
(R-HSA-8852308)
0.564
3
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.547
2
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.536
2
UniProt:Q96FJ0 STAMBPL1
1
STAMBPL1 [cytosol]
(R-HSA-6783264)
0.527
2
UniProt:P10242 MYB
1
MYB [nucleoplasm]
(R-HSA-992697)
0.499
4
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.491
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text