Dissociation of AAK1 and dephosphorylation of AP-2 mu2

Stable Identifier
R-HSA-8871193
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
clathrin-coated vesicle membrane
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Summation

GAPVD1 binds the alpha adaptin ear domain of AP-2 mu2, activating its RAB5-directed GEF activity and displacing AAK1. AAK1 displacement results in a net dephosphorylation of the AP-2 mu2 subunit, destabilizing the interaction of AP-2 with the vesicle membrane (Sato et al, 2005; Smerdjieva et al, 2008). In addition, RAB5 contributes to PI(4,5)P2 turnover through recruitment of a PI3K or PI phosphatase, and this also destabilizes the interaction of AP-2 with the membrane (Smerdjieva et al, 2008; Christoforidis et al, 1999; Shin et al, 2005).

Literature References
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Orthologous Events
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Caenorhabditis elegans)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Danio rerio)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Drosophila melanogaster)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Gallus gallus)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Sus scrofa)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Taeniopygia guttata)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Xenopus tropicalis)