RAB5 and GAPVD1 bind AP-2

Stable Identifier
R-HSA-8871194
Type
Reaction [binding]
Species
Homo sapiens
Compartment
clathrin-coated endocytic vesicle membrane
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RAB5 and GAPVD1 bind AP-2
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RAB5 is a small GTPase that is implicated in clathrin-mediated endocytosis (Chavrier et al, 1990; McLauchlan et al, 1998; Shin et al, 2002; Taylor et al, 2011; reviewed in Stenmark, 2009; Wandiger-Ness and Zerial, 2014). Recent studies have shown that RAB5 and its associated GEF GAPVD1 may contribute to AP-2 uncoating by displacing AAK1 and promoting the net dephosphorylation of the AP-2 mu2 subunit. This is predicted to destabilize interactions with the plasma membrane and promote uncoating (Sato et al, 2005; Hunker et al, 2006; Smerdjieva et al, 2008). RAB5 and GAPVD1 also increase PI(4,5)P2 turnover, likely through recruitment of a class I PI3K or a PI phosphatase (Christoforidis et al, 1999; Shin et al, 2005).

Literature References
PubMed ID Title Journal Year
15895077 Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit

Sato, M, Sato, K, Fonarev, P, Huang, CJ, Liou, W, Grant, BD

Nat. Cell Biol. 2005
16103228 An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway

Shin, HW, Hayashi, M, Christoforidis, S, Lacas-Gervais, S, Hoepfner, S, Wenk, MR, Modregger, J, Uttenweiler-Joseph, S, Wilm, M, Nystuen, A, Frankel, WN, Solimena, M, De Camilli, P, Zerial, M

J. Cell Biol. 2005
19603039 Rab GTPases as coordinators of vesicle traffic

Stenmark, H

Nat. Rev. Mol. Cell Biol. 2009
2115402 Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

Chavrier, P, Parton, RG, Hauri, HP, Simons, K, Zerial, M

Cell 1990
10559924 Phosphatidylinositol-3-OH kinases are Rab5 effectors

Christoforidis, S, Miaczynska, M, Ashman, K, Wilm, M, Zhao, L, Yip, SC, Waterfield, MD, Backer, JM, Zerial, M

Nat Cell Biol 1999
25341920 Rab proteins and the compartmentalization of the endosomal system

Wandinger-Ness, A, Zerial, M

Cold Spring Harb Perspect Biol 2014
21445324 A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis

Taylor, MJ, Perrais, D, Merrifield, CJ

PLoS Biol. 2011
16410077 Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis

Hunker, CM, Galvis, A, Kruk, I, Giambini, H, Veisaga, ML, Barbieri, MA

Biochem. Biophys. Res. Commun. 2006
18981233 Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6

Semerdjieva, S, Shortt, B, Maxwell, E, Singh, S, Fonarev, P, Hansen, J, Schiavo, G, Grant, BD, Smythe, E

J. Cell Biol. 2008
9427626 A novel role for Rab5-GDI in ligand sequestration into clathrin-coated pits

McLauchlan, H, Newell, J, Morrice, N, Osborne, A, West, M, Smythe, E

Curr. Biol. 1998
Participants
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Orthologous Events
RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
RAB5 and GAPVD1 bind AP-2 (Danio rerio)
RAB5 and GAPVD1 bind AP-2 (Drosophila melanogaster)
RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
RAB5 and GAPVD1 bind AP-2 (Mus musculus)
RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
RAB5 and GAPVD1 bind AP-2 (Schizosaccharomyces pombe)
RAB5 and GAPVD1 bind AP-2 (Xenopus tropicalis)
Cross References
Target Pathogen
Authored
Rothfels, K  (2016-05-13)
Reviewed
Antonescu, CN  (2016-05-10)
Created
Rothfels, K  (2016-05-13)
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