Reactome | RAB5 and GAPVD1 bind AP-2

RAB5 and GAPVD1 bind AP-2

Stable Identifier

R-HSA-8871194

Type

Reaction [binding]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

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RAB5 is a small GTPase that is implicated in clathrin-mediated endocytosis (Chavrier et al, 1990; McLauchlan et al, 1998; Shin et al, 2002; Taylor et al, 2011; reviewed in Stenmark, 2009; Wandiger-Ness and Zerial, 2014). Recent studies have shown that RAB5 and its associated GEF GAPVD1 may contribute to AP-2 uncoating by displacing AAK1 and promoting the net dephosphorylation of the AP-2 mu2 subunit. This is predicted to destabilize interactions with the plasma membrane and promote uncoating (Sato et al, 2005; Hunker et al, 2006; Smerdjieva et al, 2008). RAB5 and GAPVD1 also increase PI(4,5)P2 turnover, likely through recruitment of a class I PI3K or a PI phosphatase (Christoforidis et al, 1999; Shin et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
15895077	Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit Sato, M, Sato, K, Fonarev, P, Huang, CJ, Liou, W, Grant, BD	Nat. Cell Biol.	2005
16103228	An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway Shin, HW, Hayashi, M, Christoforidis, S, Lacas-Gervais, S, Hoepfner, S, Wenk, MR, Modregger, J, Uttenweiler-Joseph, S, Wilm, M, Nystuen, A, Frankel, WN, Solimena, M, De Camilli, P, Zerial, M	J. Cell Biol.	2005
19603039	Rab GTPases as coordinators of vesicle traffic Stenmark, H	Nat. Rev. Mol. Cell Biol.	2009
2115402	Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments Chavrier, P, Parton, RG, Hauri, HP, Simons, K, Zerial, M	Cell	1990
10559924	Phosphatidylinositol-3-OH kinases are Rab5 effectors Christoforidis, S, Miaczynska, M, Ashman, K, Wilm, M, Zhao, L, Yip, SC, Waterfield, MD, Backer, JM, Zerial, M	Nat Cell Biol	1999
25341920	Rab proteins and the compartmentalization of the endosomal system Wandinger-Ness, A, Zerial, M	Cold Spring Harb Perspect Biol	2014
21445324	A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis Taylor, MJ, Perrais, D, Merrifield, CJ	PLoS Biol.	2011
16410077	Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis Hunker, CM, Galvis, A, Kruk, I, Giambini, H, Veisaga, ML, Barbieri, MA	Biochem. Biophys. Res. Commun.	2006
18981233	Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6 Semerdjieva, S, Shortt, B, Maxwell, E, Singh, S, Fonarev, P, Hansen, J, Schiavo, G, Grant, BD, Smythe, E	J. Cell Biol.	2008
9427626	A novel role for Rab5-GDI in ligand sequestration into clathrin-coated pits McLauchlan, H, Newell, J, Morrice, N, Osborne, A, West, M, Smythe, E	Curr. Biol.	1998