p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP

Stable Identifier
R-HSA-8871366
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RUN and FYVE domain-containing protein 1 (RUFY1, aka RABIP4, ZFYVE12), together with Ras-related proteins RAB4A, 5 and 14, could play an important role in GLUT4 trafficking in adipocytes and skeletal muscle (Kitagishi & Matsuda 2013, Larance et al. 2005, Mari et al. 2006, Fouraux et al. 2004).

Literature References
PubMed ID Title Journal Year
16522682 The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes

Mari, M, Monzo, P, Kaddai, V, Keslair, F, Gonzalez, T, Le Marchand-Brustel, Y, Cormont, M

J. Cell. Sci. 2006
16154996 Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking

Larance, M, Ramm, G, Stöckli, J, van Dam, EM, Winata, S, Wasinger, V, Simpson, F, Graham, M, Junutula, JR, Guilhaus, M, James, DE

J. Biol. Chem. 2005
14617813 Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes

Fouraux, MA, Deneka, M, Ivan, V, van der Heijden, A, Raymackers, J, van Suylekom, D, van Venrooij, WJ, van der Sluijs, P, Pruijn, GJ

Mol. Biol. Cell 2004
23519112 RUFY, Rab and Rap Family Proteins Involved in a Regulation of Cell Polarity and Membrane Trafficking

Kitagishi, Y, Matsuda, S

Int J Mol Sci 2013
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