The sortilin-related receptor (SORL1) is expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole. It acts as a sorting receptor that mediates anterograde and retrograde movement of APP between the trans-Golgi network and early endosomes, thereby restricting delivery of the APP precursor to endocytic compartments that favour amyloidogenic peptide production (Andersen et al. 2005, Willnow & Andersen 2013, Yin et al. 2015, Hermey 2015). Targeting SORL1 might present novel opportunities for Alzheimer's disease therapy.