SORL1 transports APP(18-770) from endosome lumen to Golgi lumen

Stable Identifier
R-HSA-8871506
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The sortilin-related receptor (SORL1) is expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole. It acts as a sorting receptor that mediates anterograde and retrograde movement of APP between the trans-Golgi network and early endosomes, thereby restricting delivery of the APP precursor to endocytic compartments that favour amyloidogenic peptide production (Andersen et al. 2005, Willnow & Andersen 2013, Yin et al. 2015, Hermey 2015). Targeting SORL1 might present novel opportunities for Alzheimer's disease therapy.

Literature References
PubMed ID Title Journal Year
26807092 Intracellular sorting pathways of the amyloid precursor protein provide novel neuroprotective strategies

Hermey, G

Neural Regen Res 2015
23813966 Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease

Willnow, TE, Andersen, OM

J. Cell. Sci. 2013
16174740 Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

Andersen, OM, Reiche, J, Schmidt, V, Gotthardt, M, Spoelgen, R, Behlke, J, von Arnim, CA, Breiderhoff, T, Jansen, P, Wu, X, Bales, KR, Cappai, R, Masters, CL, Gliemann, J, Mufson, EJ, Hyman, BT, Paul, SM, Nykjaer, A, Willnow, TE

Proc. Natl. Acad. Sci. U.S.A. 2005
24833601 The Role of SORL1 in Alzheimer's Disease

Yin, RH, Yu, JT, Tan, L

Mol. Neurobiol. 2015
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