OTUD3 deubiquitinates PTEN

Stable Identifier
R-HSA-8873946
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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OTUD3 de-polyubiquitylates and stabilizes PTEN, effectively removing Lys 48-linked polyubiquitylation, but not monoubiquitylation nor the non-degradative Lys 63-linked polyubiquitylation of PTEN. In vitro OTUD3 efficiently removed the Lys 6, Lys 11, Lys 27 and Lys 48 types of ubiquitin chain on PTEN (Yuan et al. 2015).

Literature References
PubMed ID Title Journal Year
26280536 Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Yuan, L, Lv, Y, Li, H, Gao, H, Song, S, Zhang, Y, Xing, G, Kong, X, Wang, L, Li, Y, Zhou, T, Gao, D, Xiao, ZX, Yin, Y, Wei, W, He, F, Zhang, L

Nat. Cell Biol. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of OTUD3 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created