Reactome: A Curated Pathway Database

MET activates PTK2 signaling

Stable Identifier
R-HSA-8874081
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

MET receptor activates the focal adhesion kinase PTK2 (FAK1) in a process that depends on the simultaneous interaction of PTK2 with integrins and with MET. SRC is needed for PTK2 to become fully active. Activation of PTK2 is needed for HGF-induced cell motility (Beviglia et al. 1999, Parr et al. 2001, Chen and Chen 2006, Lietha et al. 2007, Chen et al. 2011, Brami-Cherrier et al. 2014).

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database