MET receptor activates the focal adhesion kinase PTK2 (FAK1) in a process that depends on the simultaneous interaction of PTK2 with integrins and with MET. SRC is needed for PTK2 to become fully active. Activation of PTK2 is needed for HGF-induced cell motility (Beviglia et al. 1999, Parr et al. 2001, Chen and Chen 2006, Lietha et al. 2007, Chen et al. 2011, Brami-Cherrier et al. 2014).
Brami-Cherrier, K, Gervasi, N, Arsenieva, D, Walkiewicz, K, Boutterin, MC, Ortega, A, Leonard, PG, Seantier, B, Gasmi, L, Bouceba, T, Kadaré, G, Girault, JA, Arold, ST
Beviglia, L, Kramer, RH
Parr, C, Davies, G, Nakamura, T, Matsumoto, K, Mason, MD, Jiang, WG
Chen, TH, Chan, PC, Chen, CL, Chen, HC
Lietha, D, Cai, X, Ceccarelli, DF, Li, Y, Schaller, MD, Eck, MJ
Chen, SY, Chen, HC
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