Reactome | MET activates PTK2 signaling

MET activates PTK2 signaling

Stable Identifier

R-HSA-8874081

Type

Pathway

Species

Homo sapiens

Locations in the PathwayBrowser

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Summation

MET receptor activates the focal adhesion kinase PTK2 (FAK1) in a process that depends on the simultaneous interaction of PTK2 with integrins and with MET. SRC is needed for PTK2 to become fully active. Activation of PTK2 is needed for HGF-induced cell motility (Beviglia et al. 1999, Parr et al. 2001, Chen and Chen 2006, Lietha et al. 2007, Chen et al. 2011, Brami-Cherrier et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24480479	FAK dimerization controls its kinase-dependent functions at focal adhesions	EMBO J.	2014
10521801	HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells	Int. J. Cancer	1999
11478803	The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variant	Biochem. Biophys. Res. Commun.	2001
20802513	Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition	Oncogene	2011
17574028	Structural basis for the autoinhibition of focal adhesion kinase	Cell	2007
16782899	Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion	Mol. Cell. Biol.	2006