MET activates PTK2 signaling

Stable Identifier
R-HSA-8874081
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

MET receptor activates the focal adhesion kinase PTK2 (FAK1) in a process that depends on the simultaneous interaction of PTK2 with integrins and with MET. SRC is needed for PTK2 to become fully active. Activation of PTK2 is needed for HGF-induced cell motility (Beviglia et al. 1999, Parr et al. 2001, Chen and Chen 2006, Lietha et al. 2007, Chen et al. 2011, Brami-Cherrier et al. 2014).

Literature References
PubMed ID Title Journal Year
24480479 FAK dimerization controls its kinase-dependent functions at focal adhesions

Brami-Cherrier, K, Gervasi, N, Arsenieva, D, Walkiewicz, K, Boutterin, MC, Ortega, A, Leonard, PG, Seantier, B, Gasmi, L, Bouceba, T, Kadaré, G, Girault, JA, Arold, ST

EMBO J. 2014
10521801 HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells

Beviglia, L, Kramer, RH

Int. J. Cancer 1999
11478803 The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variant

Parr, C, Davies, G, Nakamura, T, Matsumoto, K, Mason, MD, Jiang, WG

Biochem. Biophys. Res. Commun. 2001
20802513 Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition

Chen, TH, Chan, PC, Chen, CL, Chen, HC

Oncogene 2011
17574028 Structural basis for the autoinhibition of focal adhesion kinase

Lietha, D, Cai, X, Ceccarelli, DF, Li, Y, Schaller, MD, Eck, MJ

Cell 2007
16782899 Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion

Chen, SY, Chen, HC

Mol. Cell. Biol. 2006
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database
Authored
Reviewed