Reactome | CREB3(1-291) [Golgi membrane]

CREB3(1-291) [Golgi membrane]

Stable Identifier

R-HSA-8874181

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Cyclic AMP-responsive element-binding protein 3, CREB3_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Y287 ITM2B

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Literature References

PubMed ID	Title	Journal	Year
12138176	Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis O'Hare, P, Raggo, C, Gobeil, P, Misra, V, Smith-Windsor, E, Stirling, J, Rapin, N	Mol. Cell. Biol.	2002

External Reference Information

External Reference

UniProt:O43889 CREB3

Gene Names

CREB3, LZIP

Chain

chain:1-371, chain:1-

Reference Genes

COSMIC (genes):CREB3 CREB3

dbSNP Gene:10488 CREB3

ENSEMBL:ENSG00000107175 CREB3

Participates

as an output of

MBTPS1 (S1P) cleaves CREB3 (Homo sapiens)

as an input of

MBTPS2 (S2P) cleaves CREB3 (Homo sapiens)

Other forms of this molecule

CREB3 [endoplasmic reticulum membrane]

CREB3(292-371) [Golgi membrane]

CREB3 [Golgi membrane]

CREB3(257-291) [Golgi membrane]

CREB3(1-256) [cytosol]

CREB3(1-256) [nucleoplasm]

Inferred To

let-607 [Golgi membrane] (Caenorhabditis elegans)

Creb3 [Golgi membrane] (Mus musculus)

Creb3 [Golgi membrane] (Rattus norvegicus)

CREB3(1-291) [Golgi membrane] (Gallus gallus)

CREB3 [Golgi membrane] (Bos taurus)

CREB3 [Golgi membrane] (Canis familiaris)

CREB3 [Golgi membrane] (Sus scrofa)

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51610 HCFC1	2	K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821) HCFC1 [nucleoplasm] (R-HSA-1592209)	0.802	7
UniProt:Q92685 ALG3	5	ALG3 R171Q [endoplasmic reticulum membrane] (R-HSA-4720470) ALG3 M157K [endoplasmic reticulum membrane] (R-HSA-4720484) ALG3 G118D [endoplasmic reticulum membrane] (R-HSA-4720468) ALG3 W71R [endoplasmic reticulum membrane] (R-HSA-4720466) ALG3 [endoplasmic reticulum membrane] (R-HSA-449287)	0.729	4
UniProt:Q9NS37 ZHANG			0.623	3
UniProt:Q68CJ9 CREB3L3	10	CREB3L3(1-?) [nucleoplasm] (R-HSA-6784629) CREB3L3(1-?) [cytosol] (R-HSA-6784654) CREB3L3 [endoplasmic reticulum membrane] (R-HSA-6784669) CREB3L3(?-461) [endoplasmic reticulum membrane] (R-HSA-6784710) CREB3L3 [Golgi membrane] (R-HSA-8874144) CREB3L3(365-461) [Golgi membrane] (R-HSA-8874130) CREB3L3(1-364) [Golgi membrane] (R-HSA-8874158) CREB3L3(1-323) [cytosol] (R-HSA-8874214) CREB3L3(1-323) [nucleoplasm] (R-HSA-8874217) CREB3L3(324-364) [Golgi membrane] (R-HSA-8874183)	0.623	3
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.623	2
UniProt:O43889 CREB3	7	CREB3 [endoplasmic reticulum membrane] (R-HSA-8874165) CREB3(292-371) [Golgi membrane] (R-HSA-8874173) CREB3 [Golgi membrane] (R-HSA-8874123) CREB3(257-291) [Golgi membrane] (R-HSA-8874207) CREB3(1-291) [Golgi membrane] (R-HSA-8874181) CREB3(1-256) [cytosol] (R-HSA-8874135) CREB3(1-256) [nucleoplasm] (R-HSA-8874190)	0.592	2
UniProt:O00268 TAF4	1	TAF4 [nucleoplasm] (R-HSA-65541)	0.558	2
UniProt:Q9NX47 MARH5			0.553	2
UniProt:Q96LL9 DJC30			0.553	2
UniProt:Q99675 CGRF1			0.553	2
UniProt:Q9NQQ7 S35C2			0.553	2
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.553	2
UniProt:Q14802 FXYD3	1	FXYD3 [plasma membrane] (R-HSA-2752084)	0.553	2
UniProt:Q53HI1 UNC50			0.553	2
UniProt:Q9Y287 ITM2B	1	ITM2B(244-266) [extracellular region] (R-HSA-976878)	0.553	2
UniProt:Q9BQA9 CYBC1			0.553	2
UniProt:Q9NW97 TMM51			0.553	2
UniProt:Q9Y3D6 FIS1	2	FIS1 [peroxisomal membrane] (R-HSA-9033123) FIS1 [cytosol] (R-HSA-9033099)	0.553	2
UniProt:O95870 ABHGA			0.553	2
UniProt:Q9NV12 TM140			0.553	2
UniProt:P48230 T4S4			0.553	2
UniProt:Q9UNK0 STX8			0.553	2
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.553	2
UniProt:Q96CM8 ACSF2	1	ACSF2 [mitochondrial matrix] (R-HSA-5696005)	0.553	2
UniProt:P02652 APOA2	6	APOA2(24-100) [cytosol] (R-HSA-2395772) APOA2(24-100) [early endosome] (R-HSA-2569092) APOA2(24-100) [endoplasmic reticulum lumen] (R-HSA-174689) APOA2(24-100) [extracellular region] (R-HSA-174775) p-APOA2 [endoplasmic reticulum lumen] (R-HSA-8957014) APOA2 [endoplasmic reticulum lumen] (R-HSA-8956780)	0.553	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.524	4
UniProt:Q8TEY5 CREB3L4	7	CREB3L4(298-338) [Golgi membrane] (R-HSA-8874221) CREB3L4(1-297) [nucleoplasm] (R-HSA-8874220) CREB3L4(1-297) [cytosol] (R-HSA-8874188) CREB3L4(339-395) [Golgi membrane] (R-HSA-8874140) CREB3L4(1-338) [Golgi membrane] (R-HSA-8874180) CREB3L4 [Golgi membrane] (R-HSA-8874128) CREB3L4 [endoplasmic reticulum membrane] (R-HSA-8874168)	0.483	2

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