CREB3L1 translocates from the endoplasmic reticulum membrane to the Golgi membrane

Stable Identifier
R-HSA-8874184
Type
Reaction [omitted]
Species
Homo sapiens
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CREB3L1 (OASIS) is normally a short-lived protein located in the endoplasmic reticulum (ER) membrane (Kondo et al. 2012) of osteoblasts, astrocytes, intestine, salivary gland, and prostate. It is targeted for proteolytic degradation by HRD1 (inferred from mouse homologs). During ER stress CREB3L1 becomes stabilized and traffics by an uncharacterized mechanism to the Golgi membrane where it is cleaved by Golgi-resident proteases MBTPS1 (S1P) and MBTPS2 (S2P) (inferred from mouse homologs).

Literature References
PubMed ID Title Journal Year
22705851 Activation of OASIS family, ER stress transducers, is dependent on its stabilization

Kondo, S, Hino, SI, Saito, A, Kanemoto, S, Kawasaki, N, Asada, R, Izumi, S, Iwamoto, H, Oki, M, Miyagi, H, Kaneko, M, Nomura, Y, Urano, F, Imaizumi, K

Cell Death Differ. 2012
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