Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CREB3(1-256) [nucleoplasm]
Stable Identifier
R-HSA-8874190
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cyclic AMP-responsive element-binding protein 3, CREB3_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9Y287 ITM2B
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
CREB3 factors activate genes (Homo sapiens)
CREB3 translocates from the cytosol to the nucleus (Homo sapiens)
CREB3(1-256) [nucleoplasm] (Homo sapiens)
CREBRF binds CREB3 (Homo sapiens)
CREB3(1-256) [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
12138176
Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis
O'Hare, P
,
Raggo, C
,
Gobeil, P
,
Misra, V
,
Smith-Windsor, E
,
Stirling, J
,
Rapin, N
Mol. Cell. Biol.
2002
External Reference Information
External Reference
UniProt:O43889 CREB3
Gene Names
CREB3, LZIP
Chain
chain:1-371, chain:1-
Reference Genes
COSMIC (genes):CREB3 CREB3
dbSNP Gene:10488 CREB3
ENSEMBL:ENSG00000107175 CREB3
Participates
as an output of
CREB3 translocates from the cytosol to the nucleus (Homo sapiens)
as a component of
CREB3:CREBRF [nucleoplasm] (Homo sapiens)
as an input of
CREBRF binds CREB3 (Homo sapiens)
Other forms of this molecule
CREB3 [endoplasmic reticulum membrane]
CREB3(292-371) [Golgi membrane]
CREB3 [Golgi membrane]
CREB3(257-291) [Golgi membrane]
CREB3(1-291) [Golgi membrane]
CREB3(1-256) [cytosol]
Inferred To
CREB3 [nucleoplasm]
(Bos taurus)
CREB3 [nucleoplasm]
(Canis familiaris)
CREB3 [nucleoplasm]
(Sus scrofa)
CREB3(1-256) [nucleoplasm]
(Gallus gallus)
let-607 [nucleoplasm]
(Caenorhabditis elegans)
Creb3 [nucleoplasm]
(Mus musculus)
Creb3 [nucleoplasm]
(Rattus norvegicus)
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51610 HCFC1
2
K48polyUb,K63polyUb-HCFC1 [nucleoplasm]
(R-HSA-5690821)
HCFC1 [nucleoplasm]
(R-HSA-1592209)
0.802
7
UniProt:Q92685 ALG3
5
ALG3 R171Q [endoplasmic reticulum membrane]
(R-HSA-4720470)
ALG3 M157K [endoplasmic reticulum membrane]
(R-HSA-4720484)
ALG3 G118D [endoplasmic reticulum membrane]
(R-HSA-4720468)
ALG3 W71R [endoplasmic reticulum membrane]
(R-HSA-4720466)
ALG3 [endoplasmic reticulum membrane]
(R-HSA-449287)
0.729
4
UniProt:Q9NS37 ZHANG
0.623
3
UniProt:Q68CJ9 CREB3L3
10
CREB3L3(1-?) [nucleoplasm]
(R-HSA-6784629)
CREB3L3(1-?) [cytosol]
(R-HSA-6784654)
CREB3L3 [endoplasmic reticulum membrane]
(R-HSA-6784669)
CREB3L3(?-461) [endoplasmic reticulum membrane]
(R-HSA-6784710)
CREB3L3 [Golgi membrane]
(R-HSA-8874144)
CREB3L3(365-461) [Golgi membrane]
(R-HSA-8874130)
CREB3L3(1-364) [Golgi membrane]
(R-HSA-8874158)
CREB3L3(1-323) [cytosol]
(R-HSA-8874214)
CREB3L3(1-323) [nucleoplasm]
(R-HSA-8874217)
CREB3L3(324-364) [Golgi membrane]
(R-HSA-8874183)
0.623
3
UniProt:P35638 DDIT3
1
DDIT3 [nucleoplasm]
(R-HSA-381110)
0.623
2
UniProt:O43889 CREB3
7
CREB3 [endoplasmic reticulum membrane]
(R-HSA-8874165)
CREB3(292-371) [Golgi membrane]
(R-HSA-8874173)
CREB3 [Golgi membrane]
(R-HSA-8874123)
CREB3(257-291) [Golgi membrane]
(R-HSA-8874207)
CREB3(1-291) [Golgi membrane]
(R-HSA-8874181)
CREB3(1-256) [cytosol]
(R-HSA-8874135)
CREB3(1-256) [nucleoplasm]
(R-HSA-8874190)
0.592
2
UniProt:O00268 TAF4
1
TAF4 [nucleoplasm]
(R-HSA-65541)
0.558
2
UniProt:Q9NX47 MARH5
0.553
2
UniProt:Q96LL9 DJC30
0.553
2
UniProt:Q99675 CGRF1
0.553
2
UniProt:Q9NQQ7 S35C2
0.553
2
UniProt:Q9NZ43 USE1
1
USE1 [endoplasmic reticulum membrane]
(R-HSA-2193119)
0.553
2
UniProt:Q14802 FXYD3
1
FXYD3 [plasma membrane]
(R-HSA-2752084)
0.553
2
UniProt:Q53HI1 UNC50
0.553
2
UniProt:Q9Y287 ITM2B
1
ITM2B(244-266) [extracellular region]
(R-HSA-976878)
0.553
2
UniProt:Q9BQA9 CYBC1
0.553
2
UniProt:Q9NW97 TMM51
0.553
2
UniProt:Q9Y3D6 FIS1
2
FIS1 [peroxisomal membrane]
(R-HSA-9033123)
FIS1 [cytosol]
(R-HSA-9033099)
0.553
2
UniProt:O95870 ABHGA
0.553
2
UniProt:Q9NV12 TM140
0.553
2
UniProt:P48230 T4S4
0.553
2
UniProt:Q9UNK0 STX8
0.553
2
UniProt:P43378 PTPN9
1
PTPN9 [nucleoplasm]
(R-HSA-9008907)
0.553
2
UniProt:Q96CM8 ACSF2
1
ACSF2 [mitochondrial matrix]
(R-HSA-5696005)
0.553
2
UniProt:P02652 APOA2
6
APOA2(24-100) [cytosol]
(R-HSA-2395772)
APOA2(24-100) [early endosome]
(R-HSA-2569092)
APOA2(24-100) [endoplasmic reticulum lumen]
(R-HSA-174689)
APOA2(24-100) [extracellular region]
(R-HSA-174775)
p-APOA2 [endoplasmic reticulum lumen]
(R-HSA-8957014)
APOA2 [endoplasmic reticulum lumen]
(R-HSA-8956780)
0.553
2
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.524
4
UniProt:Q8TEY5 CREB3L4
7
CREB3L4(298-338) [Golgi membrane]
(R-HSA-8874221)
CREB3L4(1-297) [nucleoplasm]
(R-HSA-8874220)
CREB3L4(1-297) [cytosol]
(R-HSA-8874188)
CREB3L4(339-395) [Golgi membrane]
(R-HSA-8874140)
CREB3L4(1-338) [Golgi membrane]
(R-HSA-8874180)
CREB3L4 [Golgi membrane]
(R-HSA-8874128)
CREB3L4 [endoplasmic reticulum membrane]
(R-HSA-8874168)
0.483
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text