Reactome | MBTPS2 (S2P) cleaves CREB3

MBTPS2 (S2P) cleaves CREB3

Stable Identifier

R-HSA-8874192

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

ReviewStatus

5/5

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CREB3 is cleaved by regulated intramembrane proteolysis (RIP) (Raggo et al. 2002, Liang et al. 2006, Eleveld-Trancikova et al. 2010). As inferred from other RIP susbsrates, MBTPS2 (S2P) is believed to cleave CREB3 after MBTPS1 (S1P) cleaves (Raggo et al. 2002). Based on homology with cleavage sites in SREBP (SREBF) homologues, the cleavage site in CREB3 is estimated to be at about amino acid 254 at the cytoplasmic face of the transmembrane domain (Raggo et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
20546900	DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation van Hout-Kuijer, MA, Eleveld-Trancikova, D, Jansen, BJ, Sanecka, A, Adema, GJ, Hendriks, IA, Looman, MW	Mol. Immunol.	2010
16940180	Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element Lu, R, Martyn, AC, Dean, JD, Cockram, GP, Kokame, K, Li, Y, Audas, TE, Liang, G	Mol. Cell. Biol.	2006
12138176	Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis O'Hare, P, Raggo, C, Gobeil, P, Misra, V, Smith-Windsor, E, Stirling, J, Rapin, N	Mol. Cell. Biol.	2002