Reactome | MBTPS2 (S2P) cleaves CREB3L3

MBTPS2 (S2P) cleaves CREB3L3

Stable Identifier

R-HSA-8874201

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

ReviewStatus

5/5

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After cleavage by MBTPS1, CREB3L3 in the Golgi membrane is cleaved by MBTPS2 (S2P) near the cytoplasmic face of the transmembrane domain (Bailey et al. 2007, inferred from mouse homologs in Zhang et al. 2006). By inference from cleavage of SREBFs (SREBPs), CREB3L3 is believed to be cleaved at approximately amino acid residue 323. The cleavage releases the N-terminal cytoplasmic domain into the cytosol.

Literature References

PubMed ID	Title	Journal	Year
16469704	Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response Kaufman, RJ, Zhang, K, Back, SH, Shen, X, Sakaki, K, Wu, J, Rutkowski, DT, Saunders, T	Cell	2006
17875199	Trafficking of the bZIP transmembrane transcription factor CREB-H into alternate pathways of ERAD and stress-regulated intramembrane proteolysis O'Hare, P, Bailey, D, Barreca, C	Traffic	2007