MBTPS1 (S1P) cleaves CREB3

Stable Identifier
R-HSA-8874204
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the Golgi membrane, CREB3 (LUMAN) is cleaved by regulated intramembrane proteolysis (Raggo et al. 2002, Liang et al. 2006, Stirling and O'Hare 2006, Eleveld-Trancikova et al. 2010). As inferred from other cleaved proteins, the reaction is probably catalyzedby MBTPS1 (S1P) at an RQLR motif (Stirling and O'Hare 2006).

Literature References
PubMed ID Title Journal Year
16940180 Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element

Liang, G, Audas, TE, Li, Y, Cockram, GP, Dean, JD, Martyn, AC, Kokame, K, Lu, R

Mol. Cell. Biol. 2006
20546900 DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation

Eleveld-Trancikova, D, Sanecka, A, van Hout-Kuijer, MA, Looman, MW, Hendriks, IA, Jansen, BJ, Adema, GJ

Mol. Immunol. 2010
12138176 Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis

Raggo, C, Rapin, N, Stirling, J, Gobeil, P, Smith-Windsor, E, O'Hare, P, Misra, V

Mol. Cell. Biol. 2002
16236796 CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P

Stirling, J, O'Hare, P

Mol. Biol. Cell 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MBTPS1 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created