Reactome | TRAP1 [mitochondrial matrix]

TRAP1 [mitochondrial matrix]

Stable Identifier

R-HSA-8874494

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Heat shock protein 75 kDa, mitochondrial, TRAP1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q12931 TRAP1

Gene Names

TRAP1, HSP75

Chain

transit peptide:1-59, chain:60-704

Reference Genes

BioGPS Gene:10131 TRAP1

COSMIC (genes):TRAP1 TRAP1

CTD Gene:10131 TRAP1

dbSNP Gene:10131 TRAP1

ENSEMBL:ENSG00000126602 TRAP1

ENSEMBL_homo_sapiens_GENE:ENSG00000126602.11 TRAP1

HGNC:16264 TRAP1

KEGG Gene (Homo sapiens):10131 TRAP1

Monarch:10131 TRAP1

NCBI Gene:10131 TRAP1

OMIM:606219 TRAP1

UCSC:Q12931 TRAP1

Reference Transcript

Other Identifiers

10131

11715814_a_at

1468_at

16823413

201391_PM_at

201391_at

3677754

3677755

3677756

3677758

3677759

3677760

3677761

3677762

3677766

3677768

3677769

3677771

3677773

3677775

3677777

3677780

3677781

3677782

3677783

3677788

7999025

A_23_P3849

GE82100

GO:0000166

GO:0003723

GO:0003824

GO:0005164

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0005758

GO:0005759

GO:0006091

GO:0006457

GO:0009386

GO:0012501

GO:0016020

GO:0016787

GO:0016887

GO:0019901

GO:0023052

GO:0043226

GO:0044183

GO:0051082

GO:0051171

GO:0060255

GO:0061077

GO:0071944

GO:0080090

GO:0140657

GO:0140662

GO:1901856

GO:1903427

GO:1903751

HMNXSV003014700

ILMN_1699737

PH_hs_0022872

TC16000822.hg

U12595_at

g7706484_3p_at

This entity regulates

Negatively

Inferred To

hsp-75 [mitochondrial matrix] (Caenorhabditis elegans)

TRAP1 [mitochondrial matrix] (Bos taurus)

TRAP1 [mitochondrial matrix] (Canis familiaris)

TRAP1 [mitochondrial matrix] (Danio rerio)

TRAP1 [mitochondrial matrix] (Dictyostelium discoideum)

TRAP1 [mitochondrial matrix] (Gallus gallus)

TRAP1 [mitochondrial matrix] (Mus musculus)

TRAP1 [mitochondrial matrix] (Rattus norvegicus)

TRAP1 [mitochondrial matrix] (Sus scrofa)

Trap1 [mitochondrial matrix] (Drosophila melanogaster)

trap1 [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_057376.2, NP_001258978.1

Guide to Pharmacology - Targets

2909

OpenTargets

ENSG00000126602

HPA

ENSG00000126602-TRAP1

GeneCards

Q12931

ZINC target

Q12931

Ensembl

ENST00000246957, ENSP00000442070, ENSG00000126602, ENSP00000246957, ENST00000538171

PRO

Q12931

Pharos - Targets

Q12931

Orphanet

26181

PDB

7ULK, 7KLU, 4Z1F, 7U8X, 7KCM, 5HPH, 7C05, 5F5R, 7U8W, 4Z1I, 5Y3O, 7KCL, 7KCK, 5Y3N, 7U8V, 7C04, 7C7C, 4Z1H, 6XG6, 7KLV, 7U8U, 4Z1G, 7C7B, 5F3K

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BXM7-1 PINK1			0.602	4
UniProt:Q99714 HSD17B10	1	HSD17B10 [mitochondrial matrix] (R-HSA-70831)	0.499	3