EGFR gene expression is stimulated by TFAP2C

Stable Identifier
R-HSA-8874797
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of TFAP2C homodimers to the EGFR gene promoter region stimulates EGFR transcription and may play an important role in the etiology of luminal breast cancer (Park et al. 2015, de Andrade et al. 2016).

Literature References
PubMed ID Title Journal Year
25772240 The role of Tcfap2c in tumorigenesis and cancer growth in an activated Neu model of mammary carcinogenesis

Park, JM, Wu, T, Cyr, AR, Woodfield, GW, De Andrade, JP, Spanheimer, PM, Li, T, Sugg, SL, Lal, G, Domann, FE, Zhang, W, Weigel, RJ

Oncogene 2015
26832794 EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib

De Andrade, JP, Park, JM, Gu, VW, Woodfield, GW, Kulak, MV, Lorenzen, AW, Wu, VT, Van Dorin, SE, Spanheimer, PM, Weigel, RJ

Mol. Cancer Ther. 2016
Participants
Participant Of
This event is regulated
Authored
Reviewed
Created