ACSM3,ACSM6 ligate CoA to BUT

Stable Identifier
R-HSA-8875013
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Mitochondrial acyl-coenzyme A synthetase ACSM3 (aka protein SAH homolog) is expressed in the mitochondrial matrix and possesses medium-chain fatty acid:CoA ligase activity. Based on characterisation experiments in mice, ACSM3 preferentially ligates C2-C6 fatty acids, especially butyrate (BUT, a C4 fatty acid) (Fujino et al. 2001). The product, butyryl-CoA (BT-CoA) is used in beta oxidation. ACSM3 gene variants may be associated with obesity-related hypertension (Iwai et al. 1994, 2002, Telgmann et al. 2007, Tikhonoff et al. 2008). The mechanisms by which ACSM3 gene variants affect blood pressure remain to be elucidated.

Mitochondrial acyl-coenzyme A synthetase ACSM6 is proposed to be located in the mitochondrial matrix and possess the same medium-chain fatty acid:CoA ligase activity as ACSM3.

Literature References
PubMed ID Title Journal Year
11470804 Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product

Fujino, T, Takei, YA, Sone, H, Ioka, RX, Kamataki, A, Magoori, K, Takahashi, S, Sakai, J, Yamamoto, TT

J Biol Chem 2001
17278971 SAH gene variants are associated with obesity-related hypertension in Caucasians: the PEGASE Study

Telgmann, R, Brand, E, Nicaud, V, Hagedorn, C, Beining, K, SchŲnfelder, J, Brink-Spalink, V, Schmidt-Petersen, K, Matanis, T, Vischer, P, Nofer, JR, Hasenkamp, S, Plouin, PF, Drouet, L, Cambien, F, Paul, M, Tiret, L, Brand-Herrmann, SM

J. Hypertens. 2007
18192838 SAH gene variants revisited in the European Project On Genes in Hypertension

Tikhonoff, V, Staessen, JA, Kuznetsova, T, Thijs, L, Hasenkamp, S, Bšumer, V, Stolarz, K, SeidlerovŠ, J, Filipovskż, J, Nikitin, Y, Peleska, J, Kawecka-Jaszcz, K, Casiglia, E, Brand-Herrmann, SM, Brand, E

J. Hypertens. 2008
11772874 Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension

Iwai, N, Katsuya, T, Mannami, T, Higaki, J, Ogihara, T, Kokame, K, Ogata, J, Baba, S

Circulation 2002
7907320 Human SA gene locus as a candidate locus for essential hypertension

Iwai, N, Ohmichi, N, Hanai, K, Nakamura, Y, Kinoshita, M

Hypertension 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
butyrate-CoA ligase activity of ACSM3,ACSM6 [mitochondrial matrix]
Physical Entity
Activity
Inferred From
Authored
Reviewed