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GGC-RAB3A [secretory granule membrane]
Stable Identifier
R-HSA-8875319
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule membrane
Synonyms
Ras-related protein Rab-3A, RAB3A_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Rab regulation of trafficking (Homo sapiens)
RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
RAB3 GEFs exchange GTP for GDP on RAB3A (Homo sapiens)
GGC-RAB3A:GTP [secretory granule membrane] (Homo sapiens)
GGC-RAB3A [secretory granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20336 RAB3A
Gene Names
RAB3A
Chain
chain:1-220
Reference Genes
BioGPS Gene:5864 RAB3A
COSMIC (genes):RAB3A RAB3A
CTD Gene:5864 RAB3A
dbSNP Gene:5864 RAB3A
ENSEMBL:ENSG00000105649 RAB3A
ENSEMBL_homo_sapiens_GENE:ENSG00000105649.10 RAB3A
HGNC:9777 RAB3A
KEGG Gene (Homo sapiens):5864 RAB3A
Monarch:5864 RAB3A
NCBI Gene:5864 RAB3A
OMIM:179490 RAB3A
UCSC:P20336 RAB3A
Reference Transcript
RefSeq:NM_002866.4 RAB3A
RefSeq:XM_011528164.1 RAB3A
Other Identifiers
11723977_at
11723978_x_at
11748842_a_at
16870329
204974_PM_at
204974_at
3854757
3854758
3854760
3854761
3854763
3854766
57558_at
5864
620_at
8035398
A_23_P108200
A_33_P3314550
GE57899
GO:0000166
GO:0001669
GO:0001778
GO:0003016
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005576
GO:0005737
GO:0005764
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0006886
GO:0006887
GO:0006904
GO:0007005
GO:0007274
GO:0007409
GO:0008021
GO:0008092
GO:0009306
GO:0009791
GO:0015031
GO:0016020
GO:0016079
GO:0016188
GO:0016192
GO:0016787
GO:0017156
GO:0017157
GO:0022414
GO:0023052
GO:0030073
GO:0030133
GO:0030154
GO:0030324
GO:0030424
GO:0030667
GO:0030672
GO:0030674
GO:0030742
GO:0031410
GO:0031489
GO:0031630
GO:0031982
GO:0032418
GO:0034330
GO:0036465
GO:0042060
GO:0042995
GO:0043195
GO:0043226
GO:0045054
GO:0045055
GO:0045202
GO:0045921
GO:0048172
GO:0048471
GO:0048489
GO:0048786
GO:0048790
GO:0048856
GO:0050877
GO:0050975
GO:0051602
GO:0051649
GO:0060090
GO:0060201
GO:0060203
GO:0060478
GO:0061024
GO:0061202
GO:0061670
GO:0070083
GO:0072659
GO:0097091
GO:0098793
GO:0098794
GO:0099161
GO:1903307
GO:1903561
GO:1905684
HMNXSV003030499
Hs.27744.0.S2_3p_at
Hs.27744.0.S2_3p_x_at
ILMN_1755369
M28210_at
TC19001282.hg
Participates
as a component of
GGC-RAB3A:GTP [secretory granule membrane] (Homo sapiens)
Other forms of this molecule
RAB3A [clathrin-sculpted monoamine transport vesicle membrane]
RAB3A [plasma membrane]
RAB3A [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
RAB3A [clathrin-sculpted glutamate transport vesicle membrane]
RAB3A [secretory granule membrane]
RAB3A [clathrin-sculpted acetylcholine transport vesicle membrane]
RAB3A [cytosol]
GGC-RAB3A [cytosol]
Inferred To
GGC-RAB3A [secretory granule membrane]
(Bos taurus)
GGC-RAB3A [secretory granule membrane]
(Caenorhabditis elegans)
GGC-RAB3A [secretory granule membrane]
(Dictyostelium discoideum)
GGC-RAB3A [secretory granule membrane]
(Drosophila melanogaster)
GGC-RAB3A [secretory granule membrane]
(Gallus gallus)
GGC-RAB3A [secretory granule membrane]
(Mus musculus)
GGC-RAB3A [secretory granule membrane]
(Rattus norvegicus)
GGC-RAB3A [secretory granule membrane]
(Saccharomyces cerevisiae)
GGC-RAB3A [secretory granule membrane]
(Schizosaccharomyces pombe)
GGC-RAB3A [secretory granule membrane]
(Sus scrofa)
RAB3A [secretory granule membrane]
(Canis familiaris)
rab3ab [secretory granule membrane]
(Danio rerio)
Homologues of GGC-RAB3A [secretory granule membrane]
(Dictyostelium discoideum)
Homologues of GGC-RAB3A [secretory granule membrane]
(Schizosaccharomyces pombe)
Homologues of GGC-RAB3A [secretory granule membrane]
(Sus scrofa)
rab3a [secretory granule membrane]
(Xenopus tropicalis)
Modified Residues
Name
S-geranylgeranyl-L-cysteine at 218
Coordinate
218
PsiMod Name
S-geranylgeranyl-L-cysteine [MOD:00113]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.
Name
S-geranylgeranyl-L-cysteine at 220
Coordinate
220
PsiMod Name
S-geranylgeranyl-L-cysteine [MOD:00113]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.
Cross References
RefSeq
NP_002857.1
,
XP_011526466.1
OpenTargets
ENSG00000105649
HPA
ENSG00000105649-RAB3A
GeneCards
P20336
Ensembl
ENSG00000105649
,
ENSP00000222256
,
ENST00000222256
PRO
P20336
Pharos - Targets
P20336
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P47224 MSS4
0.782
11
UniProt:P50395 GDI2
4
GDI2 [cytosol]
(R-HSA-195089)
GDI2 [secretory granule lumen]
(R-HSA-6800904)
GDI2 [extracellular region]
(R-HSA-6806176)
GDI2 [azurophil granule lumen]
(R-HSA-6799337)
0.643
3
UniProt:P31150 GDI1
1
GDI1 [cytosol]
(R-HSA-195106)
0.643
3
UniProt:Q96QF0 RAB3IP
1
RAB3IP [cytosol]
(R-HSA-5617610)
0.556
3
UniProt:Q8TBN0 RAB3IL1
1
RAB3IL1 [cytosol]
(R-HSA-8875296)
0.556
3
UniProt:Q96QF0-7 RAB3IP
0.556
3
UniProt:Q9H8Y1 VRTN
0.556
5
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q9NVT9 ARMC1
0.527
2
UniProt:Q8N398 VW5B2
0.527
3
UniProt:P26374 CHML
1
CHML [cytosol]
(R-HSA-8870443)
0.527
3
UniProt:P24386 CHM
1
CHM [cytosol]
(R-HSA-6801097)
0.527
3
UniProt:Q96C24 SYTL4
2
SYTL4 [platelet alpha granule membrane]
(R-HSA-8862959)
SYTL4 [plasma membrane]
(R-HSA-8862971)
0.527
3
UniProt:Q9UHK0 NUFP1
0.527
2
UniProt:Q9H082 RAB33B
4
GGC-RAB33B [Golgi membrane]
(R-HSA-6810968)
RAB33B [Golgi membrane]
(R-HSA-8854609)
GGC-RAB33B [cytosol]
(R-HSA-8874107)
RAB33B [cytosol]
(R-HSA-8873702)
0.527
3
UniProt:Q9HD47 RANGRF
1
RANGRF [cytosol]
(R-HSA-5216063)
0.527
3
UniProt:P20337 RAB3B
2
GGC-RAB3B [cytosol]
(R-HSA-8874009)
RAB3B [cytosol]
(R-HSA-8873715)
0.527
2
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