InlB-mediated entry of Listeria monocytogenes into host cell

Stable Identifier
R-HSA-8875360
Type
Pathway
Species
Homo sapiens
Related Species
Listeria monocytogenes
Locations in the PathwayBrowser
Summation

InlB, a cell wall protein of Listeria monocytogenes, binds MET receptor, acting as an HGF agonist (Shen et al. 2000, Veiga and Cossart 2005). Listeria monocytogenes InlB proteins dimerize through their leucine-rich repeat regions (LRRs), promoting dimerization of MET receptors that they are bound to (Ferraris et al. 2010). InlB-induced MET receptor dimerization is followed by MET trans-autophosphorylation and activation of downstream RAS/RAF/MAPK signaling and PI3K/AKT signaling (Niemann et al. 2007, Ferraris et al. 2010). InlB-bound phosphorylated MET receptor recruits the E3 ubiquitin ligase CBL through GRB2. CBL-mediated monoubiquitination of InlB-bound MET promotes endocytosis and entry of Listeria monocytogenes to host cells (Veiga and Cossart 2005). CIN85 is necessary for endocytosis-mediated entry of Listeria monocytogenes triggered by CBL-mediated monoubiquitination of MET (Veiga and Cossart 2005). Proteins involved in clathrin-mediated endocytosis EPS15 and HGS (Hrs) are both necessary for CBL and MET-mediated entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005).
A potential coreceptor role of CD44 in InlB-mediated MET activation is contradictory (Jung et al. 2009, Dortet et al. 2010).

Literature References
PubMed ID Title Journal Year
16113677 Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells

Veiga, E, Cossart, P

Nat. Cell Biol. 2005
19900460 Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB

Ferraris, DM, Gherardi, E, Di, Y, Heinz, DW, Niemann, HH

J. Mol. Biol. 2010
11081636 InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase

Shen, Y, Naujokas, M, Park, M, Ireton, K

Cell 2000
17662939 Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB

Niemann, HH, Jäger, V, Butler, PJ, van den Heuvel, J, Schmidt, S, Ferraris, D, Gherardi, E, Heinz, DW

Cell 2007
19432801 Involvement of CD44v6 in InlB-dependent Listeria invasion

Jung, C, Matzke, A, Niemann, HH, Schwerk, C, Tenenbaum, T, Orian-Rousseau, V

Mol. Microbiol. 2009
20670691 CD44-independent activation of the Met signaling pathway by HGF and InlB

Dortet, L, Veiga, E, Bonazzi, M, Cossart, P

Microbes Infect. 2010
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
listeriosis 11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Cross References
BioModels Database
Authored
Reviewed